Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC

•Arsenic delays removal of UV-induced photolesions.•Arsenic reduces XPC protein expression.•Arsenic reduces XPC, XPA, and DDB2 RNA expression.•Arsenic-mediated XPC protein inhibition is proteasome dependent. Chronic exposure to arsenic, most often through contaminated drinking water, has been linked...

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Veröffentlicht in:	DNA repair 2017-04, Vol.52, p.70-80
Hauptverfasser:	Holcomb, Nathaniel, Goswami, Mamta, Han, Sung Gu, Scott, Tim, D’Orazio, John, Orren, David K., Gairola, C. Gary, Mellon, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic Arsenites - pharmacology Arsenites - toxicity DNA - metabolism DNA - radiation effects DNA Damage DNA Repair - drug effects DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - radiation effects Gene Expression Regulation Humans Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Kinetics Lung cancer Mice Nucleotide excision repair Pyrimidine Dimers - metabolism Skin cancer Sodium Compounds - pharmacology Sodium Compounds - toxicity Ultraviolet Rays UV light XPC
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