Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by tran...
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| Veröffentlicht in: | Disease markers 2017-01, Vol.2017 (2017), p.1-11 |
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| creator | Ferreira, Junia Raquel Dutra Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza Pitanga, Thassila Nogueira Fiuza, Luciana Magalhães Figueiredo, Camylla Vilas Boas Guarda, Caroline Conceição Santana, Sânzio Silva Adanho, Corynne Stephanie Ahouefa Vieira, Camilo Santiago, Rayra Pereira Aleluia, Milena Magalhães |
| description | Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children. |
| doi_str_mv | 10.1155/2017/6359871 |
| format | Article |
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T. ; Dennis W T Nilsen</contributor><creatorcontrib>Ferreira, Junia Raquel Dutra ; Oliveira, Rodrigo Mota ; Zanette, Dalila Luciola ; Lyra, Isa Menezes ; Goncalves, Marilda Souza ; Pitanga, Thassila Nogueira ; Fiuza, Luciana Magalhães ; Figueiredo, Camylla Vilas Boas ; Guarda, Caroline Conceição ; Santana, Sânzio Silva ; Adanho, Corynne Stephanie Ahouefa ; Vieira, Camilo ; Santiago, Rayra Pereira ; Aleluia, Milena Magalhães ; Nilsen, Dennis W. T. ; Dennis W T Nilsen</creatorcontrib><description>Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2017/6359871</identifier><identifier>PMID: 28790534</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Analysis ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - genetics ; Anemia, Sickle Cell - physiopathology ; Bilirubin ; Bilirubin - blood ; Biological markers ; Biomarkers ; Biomarkers - blood ; Blood ; Blood Cell Count ; Blood flow ; Blood Flow Velocity ; Case-Control Studies ; Cerebral blood flow ; Cerebral circulation ; Cerebrovascular Circulation ; Child ; Children ; Circulatory system ; Erythrocytes ; Female ; Ferritin ; Ferritins - blood ; Flow velocity ; Genetic analysis ; Genetic aspects ; Haplotypes ; Hematocrit ; Hematology ; Hemoglobin ; Hemoglobin, Sickle - genetics ; Hemoglobin, Sickle - metabolism ; Humans ; Immunology ; Infant ; Laboratories ; Male ; Monocytes ; Multivariate analysis ; Nitric oxide ; Nitric Oxide - blood ; Nitrogen oxides ; Pediatric research ; Sickle cell anemia ; Ultrasound</subject><ispartof>Disease markers, 2017-01, Vol.2017 (2017), p.1-11</ispartof><rights>Copyright © 2017 Rayra Pereira Santiago et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Rayra Pereira Santiago et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Rayra Pereira Santiago et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-624ff8b12477197da4c7403038395f994f7a348742a3f32c7fab49b96cf176333</citedby><cites>FETCH-LOGICAL-c499t-624ff8b12477197da4c7403038395f994f7a348742a3f32c7fab49b96cf176333</cites><orcidid>0000-0003-3000-1437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28790534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nilsen, Dennis W. T.</contributor><contributor>Dennis W T Nilsen</contributor><creatorcontrib>Ferreira, Junia Raquel Dutra</creatorcontrib><creatorcontrib>Oliveira, Rodrigo Mota</creatorcontrib><creatorcontrib>Zanette, Dalila Luciola</creatorcontrib><creatorcontrib>Lyra, Isa Menezes</creatorcontrib><creatorcontrib>Goncalves, Marilda Souza</creatorcontrib><creatorcontrib>Pitanga, Thassila Nogueira</creatorcontrib><creatorcontrib>Fiuza, Luciana Magalhães</creatorcontrib><creatorcontrib>Figueiredo, Camylla Vilas Boas</creatorcontrib><creatorcontrib>Guarda, Caroline Conceição</creatorcontrib><creatorcontrib>Santana, Sânzio Silva</creatorcontrib><creatorcontrib>Adanho, Corynne Stephanie Ahouefa</creatorcontrib><creatorcontrib>Vieira, Camilo</creatorcontrib><creatorcontrib>Santiago, Rayra Pereira</creatorcontrib><creatorcontrib>Aleluia, Milena Magalhães</creatorcontrib><title>Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.</description><subject>Adolescent</subject><subject>Analysis</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - genetics</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>Bilirubin</subject><subject>Bilirubin - blood</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood Cell Count</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Case-Control Studies</subject><subject>Cerebral blood flow</subject><subject>Cerebral circulation</subject><subject>Cerebrovascular Circulation</subject><subject>Child</subject><subject>Children</subject><subject>Circulatory system</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Flow velocity</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Haplotypes</subject><subject>Hematocrit</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Hemoglobin, Sickle - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infant</subject><subject>Laboratories</subject><subject>Male</subject><subject>Monocytes</subject><subject>Multivariate analysis</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Nitrogen oxides</subject><subject>Pediatric research</subject><subject>Sickle cell anemia</subject><subject>Ultrasound</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEURi0EoiGwY40ssUGCUD_H9gYpDbRFisSCx9byeK4Tl8m42BOi_HscJbTAipUt-ejc-_lD6DklbymV8pwRqs4bLo1W9AGaUK3kTDecPEQTwpSeESbIGXpSyg0hlBlhHqMzppUhkosJWi1dm7IbU95jN3T4CgYYo8cXMW1c_g654HkpyUc3Qod3cVzjBWRos-vxRZ9Shy_7tMPfoK_MuMdxwNewSas-tfX6eYHfxwKuwFP0KLi-wLPTOUVfLz98WVzPlp-uPi7my5kXxoyzhokQdEuZUIoa1TnhlSCccM2NDMaIoBwXWgnmeODMq-BaYVrT-EBVwzmfondH7-223UDnYRjrqvY2xxpnb5OL9u-XIa7tKv20sn4H06IKXp0EOf3YQhntJhYPfe8GSNtiqWGqIbRhuqIv_0Fv0jYPNZ6tpRCtGiP4PbVyPdg4hFTn-oPUzqWsnUhSZ0_RmyPlcyolQ7hbmRJ76PmgVPbUc8Vf_BnzDv5dbAVeH4F1HDq3i_-pg8pAcPc0lUxwxX8BSra3yA</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Ferreira, Junia Raquel Dutra</creator><creator>Oliveira, Rodrigo Mota</creator><creator>Zanette, Dalila Luciola</creator><creator>Lyra, Isa Menezes</creator><creator>Goncalves, Marilda Souza</creator><creator>Pitanga, Thassila Nogueira</creator><creator>Fiuza, Luciana Magalhães</creator><creator>Figueiredo, Camylla Vilas Boas</creator><creator>Guarda, Caroline Conceição</creator><creator>Santana, Sânzio Silva</creator><creator>Adanho, Corynne Stephanie Ahouefa</creator><creator>Vieira, Camilo</creator><creator>Santiago, Rayra Pereira</creator><creator>Aleluia, Milena Magalhães</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid></search><sort><creationdate>20170101</creationdate><title>Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease</title><author>Ferreira, Junia Raquel Dutra ; Oliveira, Rodrigo Mota ; Zanette, Dalila Luciola ; Lyra, Isa Menezes ; Goncalves, Marilda Souza ; Pitanga, Thassila Nogueira ; Fiuza, Luciana Magalhães ; Figueiredo, Camylla Vilas Boas ; Guarda, Caroline Conceição ; Santana, Sânzio Silva ; Adanho, Corynne Stephanie Ahouefa ; Vieira, Camilo ; Santiago, Rayra Pereira ; Aleluia, Milena Magalhães</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-624ff8b12477197da4c7403038395f994f7a348742a3f32c7fab49b96cf176333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Analysis</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - genetics</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>Bilirubin</topic><topic>Bilirubin - blood</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Blood Cell Count</topic><topic>Blood flow</topic><topic>Blood Flow Velocity</topic><topic>Case-Control Studies</topic><topic>Cerebral blood flow</topic><topic>Cerebral circulation</topic><topic>Cerebrovascular Circulation</topic><topic>Child</topic><topic>Children</topic><topic>Circulatory system</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Flow velocity</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Haplotypes</topic><topic>Hematocrit</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Hemoglobin, Sickle - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infant</topic><topic>Laboratories</topic><topic>Male</topic><topic>Monocytes</topic><topic>Multivariate analysis</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Nitrogen oxides</topic><topic>Pediatric research</topic><topic>Sickle cell anemia</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, Junia Raquel Dutra</creatorcontrib><creatorcontrib>Oliveira, Rodrigo Mota</creatorcontrib><creatorcontrib>Zanette, Dalila Luciola</creatorcontrib><creatorcontrib>Lyra, Isa Menezes</creatorcontrib><creatorcontrib>Goncalves, Marilda Souza</creatorcontrib><creatorcontrib>Pitanga, Thassila Nogueira</creatorcontrib><creatorcontrib>Fiuza, Luciana Magalhães</creatorcontrib><creatorcontrib>Figueiredo, Camylla Vilas Boas</creatorcontrib><creatorcontrib>Guarda, Caroline Conceição</creatorcontrib><creatorcontrib>Santana, Sânzio Silva</creatorcontrib><creatorcontrib>Adanho, Corynne Stephanie Ahouefa</creatorcontrib><creatorcontrib>Vieira, Camilo</creatorcontrib><creatorcontrib>Santiago, Rayra Pereira</creatorcontrib><creatorcontrib>Aleluia, Milena Magalhães</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, Junia Raquel Dutra</au><au>Oliveira, Rodrigo Mota</au><au>Zanette, Dalila Luciola</au><au>Lyra, Isa Menezes</au><au>Goncalves, Marilda Souza</au><au>Pitanga, Thassila Nogueira</au><au>Fiuza, Luciana Magalhães</au><au>Figueiredo, Camylla Vilas Boas</au><au>Guarda, Caroline Conceição</au><au>Santana, Sânzio Silva</au><au>Adanho, Corynne Stephanie Ahouefa</au><au>Vieira, Camilo</au><au>Santiago, Rayra Pereira</au><au>Aleluia, Milena Magalhães</au><au>Nilsen, Dennis W. T.</au><au>Dennis W T Nilsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28790534</pmid><doi>10.1155/2017/6359871</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Analysis Anemia, Sickle Cell - blood Anemia, Sickle Cell - genetics Anemia, Sickle Cell - physiopathology Bilirubin Bilirubin - blood Biological markers Biomarkers Biomarkers - blood Blood Blood Cell Count Blood flow Blood Flow Velocity Case-Control Studies Cerebral blood flow Cerebral circulation Cerebrovascular Circulation Child Children Circulatory system Erythrocytes Female Ferritin Ferritins - blood Flow velocity Genetic analysis Genetic aspects Haplotypes Hematocrit Hematology Hemoglobin Hemoglobin, Sickle - genetics Hemoglobin, Sickle - metabolism Humans Immunology Infant Laboratories Male Monocytes Multivariate analysis Nitric oxide Nitric Oxide - blood Nitrogen oxides Pediatric research Sickle cell anemia Ultrasound |
| title | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
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