Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor

Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed in mammalian cells. It was first identified in Peutz-Jeghers syndrome as a tumor suppressor gene. Whether endothelial LKB1 regulates angiogenesis and tumor growth is unknown. In this study, we generated endothelial ce...

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Veröffentlicht in:	Oncogene 2017-07, Vol.36 (30), p.4277-4287
Hauptverfasser:	Zhang, W, Ding, Y, Zhang, C, Lu, Q, Liu, Z, Coughlan, K, Okon, I, Zou, M-H
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 13/51 42/41 45/29 45/70 631/67/327 631/80/304 82/80 96/95 Angiogenesis Animals Apoptosis Cadherins Cell Biology Cell proliferation Clonal deletion Cross-breeding Endothelial cells Endothelial growth factors Gene Expression Regulation, Neoplastic - physiology Hepatocytes Human Genetics Injection Internal Medicine Kidneys Kinases Leukocyte migration Liver LKB1 protein Lungs Macrophages Mammalian cells Medicine Medicine & Public Health Melanoma, Experimental - pathology Mice Mice, Knockout Neovascularization Neovascularization, Pathologic - metabolism Oncology original-article Permeability Peutz-Jeghers syndrome Protein kinase Protein-Serine-Threonine Kinases - deficiency Protein-serine/threonine kinase Retina Ribonucleic acid RNA Rodents siRNA Skin Sp1 protein Sp1 Transcription Factor - metabolism Tumor suppressor genes Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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