Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain barrier (BBB) and then across the astrocytic glia limitans (GL). Factors secre...

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Veröffentlicht in:	The Journal of clinical investigation 2017-08, Vol.127 (8), p.3136-3151
Hauptverfasser:	Horng, Sam, Therattil, Anthony, Moyon, Sarah, Gordon, Alexandra, Kim, Karla, Argaw, Azeb Tadesse, Hara, Yuko, Mariani, John N, Sawai, Setsu, Flodby, Per, Crandall, Edward D, Borok, Zea, Sofroniew, Michael V, Chapouly, Candice, John, Gareth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Astrocytes Astrocytes - cytology Biomedical research Blood-brain barrier Blood-Brain Barrier - pathology Breakdowns Cell Adhesion Molecules - metabolism Central nervous system Central Nervous System - pathology Central nervous system diseases Claudin-1 - metabolism Claudin-4 - metabolism Coculture Techniques Cytokines Cytokines - metabolism Disease Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - pathology Female Genetic aspects Humans Inflammation Leukocytes Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Mortality Motor task performance Multiple sclerosis Multiple Sclerosis - pathology Nervous System Diseases - pathology Neuropathology Pathogenesis Permeability Proteins Receptors, Cell Surface - metabolism Rodents Studies Tight Junctions
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