S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure

Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent activator of endothelial nitric oxide synthase through G protein-coupled receptors. Endothelial-derived S1P and the au...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-08, Vol.70 (2), p.426-434
Hauptverfasser:	Cantalupo, Anna, Gargiulo, Antonella, Dautaj, Elona, Liu, Catherine, Zhang, Yi, Hla, Timothy, Di Lorenzo, Annarita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Blood Pressure - physiology Disease Models, Animal Endothelial Cells - metabolism Fingolimod Hydrochloride - pharmacology Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology Immunosuppressive Agents - pharmacology Mice Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Receptors, Lysosphingolipid - antagonists & inhibitors Receptors, Lysosphingolipid - metabolism Signal Transduction - drug effects Signal Transduction - physiology
Online-Zugang:	Volltext
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