The status of immunosuppression in patients with stage IIIB or IV non-small-cell lung cancer correlates with the clinical characteristics and response to chemotherapy

Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step of tryptophan (Trp) degradation via the kynurenine (Kyn) pathway, which inhibits the proliferation of T cells and induces the apoptosis of T cells, leading to immune tolerance. Therefore, IDO has been considered as the most important...

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Veröffentlicht in:	OncoTargets and therapy 2017-01, Vol.10, p.3557-3566
Hauptverfasser:	Wang, Yuan, Hu, Guo-Fang, Wang, Zhe-Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Chemotherapy Dendritic cells Development and progression Esophagus Hematology Immune system Immunological tolerance Immunotherapy Lung cancer Lymphatic system Lymphocytes Lymphoma Medical prognosis Melanoma Metabolites Metastasis Methods NMR Non-small cell lung cancer Nuclear magnetic resonance Original Research Patient outcomes Patients Skin cancer Studies Tumors Womens health
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