Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice

Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial homeostasis and has been implicated in the suppression of colitis and colon cancer. In this study, we investigated the cGMP-elevating ability of the phosphodiesterase-5 (PDE5) inhibitor sildenafil to prevent disease in t...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2017-07, Vol.10 (7), p.377-388
Hauptverfasser:	Islam, Bianca N, Sharman, Sarah K, Hou, Yali, Bridges, Allison E, Singh, Nagendra, Kim, Sangmi, Kolhe, Ravindra, Trillo-Tinoco, Jimena, Rodriguez, Paulo C, Berger, Franklin G, Sridhar, Subbaramiah, Browning, Darren D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Apoptosis - drug effects Azoxymethane - toxicity Carcinogenesis - drug effects Colitis - chemically induced Colitis - complications Colitis - drug therapy Colon - drug effects Colon - pathology Colorectal Neoplasms - etiology Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Cyclic GMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Dextran Sulfate - toxicity Humans Immunohistochemistry Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Male Mice Mice, Inbred C57BL Neoplasms, Experimental - etiology Neoplasms, Experimental - pathology Neoplasms, Experimental - prevention & control Phosphodiesterase 5 Inhibitors - therapeutic use Polyps - etiology Polyps - pathology Polyps - prevention & control Signal Transduction - drug effects Sildenafil Citrate - therapeutic use
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