Rapid and reversible disappearance of beta‐adrenergic cell surface receptors

The water soluble beta‐adrenergic ligand [3H]CGP‐12177 was used to measure the cell surface receptors in intact cells. In two cell lines, C6 glioma and WEHI 7 lymphoma cells, ‐50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol. The receptors can...

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Veröffentlicht in:	The EMBO journal 1982-01, Vol.1 (2), p.187-190
Hauptverfasser:	Staehelin, M., Simons, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta -adrenergic Cell Line endocytosis Endocytosis - drug effects Glioma - metabolism glioma cells isoproterenol Isoproterenol - pharmacology lymphoma Lymphoma - metabolism Propanolamines - metabolism Receptors, Adrenergic, beta - metabolism Time Factors
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