Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy
MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, in...
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| Veröffentlicht in: | Oncology letters 2017-08, Vol.14 (2), p.1215-1222 |
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| container_title | Oncology letters |
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| creator | Huang, Ling-Li Huang, Ling-Wei Wang, Lei Tong, Ben-Ding Wei, Qing Ding, Xuan-Sheng |
| description | MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a promising biomarker for cancer diagnosis, prognosis and therapy. miR-139-5p is expected to serve as a biomarker to eventually be implemented in a clinical setting. In the present review, we focus on the importance of miR-139-5p in cancer, summarize the association between miR-139-5p expression level and diagnosis and prognosis, and discuss the potential therapeutic implications for the future. |
| doi_str_mv | 10.3892/ol.2017.6351 |
| format | Article |
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Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a promising biomarker for cancer diagnosis, prognosis and therapy. miR-139-5p is expected to serve as a biomarker to eventually be implemented in a clinical setting. In the present review, we focus on the importance of miR-139-5p in cancer, summarize the association between miR-139-5p expression level and diagnosis and prognosis, and discuss the potential therapeutic implications for the future.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2017.6351</identifier><identifier>PMID: 28789336</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Apoptosis ; Bladder cancer ; Breast cancer ; cancer ; Cancer diagnosis ; Cancer therapies ; Cell cycle ; Clinical medicine ; Colorectal cancer ; diagnosis ; Esophagus ; Gastric cancer ; Genes ; Health aspects ; Innovations ; Liver cancer ; Lung cancer ; Medical diagnosis ; Medical prognosis ; Metastasis ; MicroRNA ; microRNA-139-5p ; Molecular diagnostic techniques ; Oncology ; Oral cancer ; Ovarian cancer ; Pancreatic cancer ; Phase transitions ; prognosis ; Proteins ; Review ; RNA polymerase ; Studies ; therapy ; Thyroid gland</subject><ispartof>Oncology letters, 2017-08, Vol.14 (2), p.1215-1222</ispartof><rights>Copyright: © Huang et al.</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright: © Huang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-17a625a4ae65f5483e0e73885deadcf97633f3ca114205a46e89a84923aba173</citedby><cites>FETCH-LOGICAL-c605t-17a625a4ae65f5483e0e73885deadcf97633f3ca114205a46e89a84923aba173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529864/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529864/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,5569,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28789336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Ling-Li</creatorcontrib><creatorcontrib>Huang, Ling-Wei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Tong, Ben-Ding</creatorcontrib><creatorcontrib>Wei, Qing</creatorcontrib><creatorcontrib>Ding, Xuan-Sheng</creatorcontrib><title>Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a promising biomarker for cancer diagnosis, prognosis and therapy. miR-139-5p is expected to serve as a biomarker to eventually be implemented in a clinical setting. In the present review, we focus on the importance of miR-139-5p in cancer, summarize the association between miR-139-5p expression level and diagnosis and prognosis, and discuss the potential therapeutic implications for the future.</description><subject>Apoptosis</subject><subject>Bladder cancer</subject><subject>Breast cancer</subject><subject>cancer</subject><subject>Cancer diagnosis</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Clinical medicine</subject><subject>Colorectal cancer</subject><subject>diagnosis</subject><subject>Esophagus</subject><subject>Gastric cancer</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Innovations</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>microRNA-139-5p</subject><subject>Molecular diagnostic techniques</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Ovarian cancer</subject><subject>Pancreatic cancer</subject><subject>Phase transitions</subject><subject>prognosis</subject><subject>Proteins</subject><subject>Review</subject><subject>RNA polymerase</subject><subject>Studies</subject><subject>therapy</subject><subject>Thyroid gland</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkl1LHDEUhodSqWK963UZaCleONt8TL5uBBFrCwuKeB-OmcxuJJNMk5mC_77Zrt26xZyLHJLnvElO3qr6gNGCSkW-Rr8gCIsFpwy_qY6wUKTBSJK3u1y0h9VJzo-oDMaxlPxddUikkIpSflRd38bJhsmBr1P0to59Pbi7BlPVsLF2oTYQjE1152AVYnb5rB5T3KY1hK6e1jbB-PS-OujBZ3vyPB9X99-u7i-_N8ub6x-XF8vGcMSmBgvghEELlrOetZJaZAWVknUWOtMrwSntqQGMW4IKx61UIFtFKDwAFvS4Ot_KjvPDYDtTrp7A6zG5AdKTjuD0_k5wa72KvzRjREneFoHTZ4EUf842T3pw2VjvIdg4Z40VEUwJ1aqCfvoPfYxzCuV1hSoEE5jIf9QKvNUu9LGcazai-oKhtvwCbWmhFq9QJTo7OBOD7V1Z3yv48qJgbcFP6xz9PLkY8j54tgVNijkn2--agZHeeERHrzce0RuPFPzjywbu4L-OKMDnLZDH8r2ui3nH3CwbVOKPzm_CJr7_</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Huang, Ling-Li</creator><creator>Huang, Ling-Wei</creator><creator>Wang, Lei</creator><creator>Tong, Ben-Ding</creator><creator>Wei, Qing</creator><creator>Ding, Xuan-Sheng</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy</title><author>Huang, Ling-Li ; Huang, Ling-Wei ; Wang, Lei ; Tong, Ben-Ding ; Wei, Qing ; Ding, Xuan-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-17a625a4ae65f5483e0e73885deadcf97633f3ca114205a46e89a84923aba173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apoptosis</topic><topic>Bladder cancer</topic><topic>Breast cancer</topic><topic>cancer</topic><topic>Cancer diagnosis</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Clinical medicine</topic><topic>Colorectal cancer</topic><topic>diagnosis</topic><topic>Esophagus</topic><topic>Gastric cancer</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Innovations</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>microRNA-139-5p</topic><topic>Molecular diagnostic techniques</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>Ovarian cancer</topic><topic>Pancreatic cancer</topic><topic>Phase transitions</topic><topic>prognosis</topic><topic>Proteins</topic><topic>Review</topic><topic>RNA polymerase</topic><topic>Studies</topic><topic>therapy</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Ling-Li</creatorcontrib><creatorcontrib>Huang, Ling-Wei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Tong, Ben-Ding</creatorcontrib><creatorcontrib>Wei, Qing</creatorcontrib><creatorcontrib>Ding, Xuan-Sheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Ling-Li</au><au>Huang, Ling-Wei</au><au>Wang, Lei</au><au>Tong, Ben-Ding</au><au>Wei, Qing</au><au>Ding, Xuan-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>14</volume><issue>2</issue><spage>1215</spage><epage>1222</epage><pages>1215-1222</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. 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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Apoptosis Bladder cancer Breast cancer cancer Cancer diagnosis Cancer therapies Cell cycle Clinical medicine Colorectal cancer diagnosis Esophagus Gastric cancer Genes Health aspects Innovations Liver cancer Lung cancer Medical diagnosis Medical prognosis Metastasis MicroRNA microRNA-139-5p Molecular diagnostic techniques Oncology Oral cancer Ovarian cancer Pancreatic cancer Phase transitions prognosis Proteins Review RNA polymerase Studies therapy Thyroid gland |
| title | Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy |
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