Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia

The transcription factor TAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-ALL), a malignant disorder resulting from leukemic transformation of thymus T-cell precursors. TAL1 is normally expressed in hematopoietic stem cells (HSCs) but is silenced in immature...

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Veröffentlicht in:	Leukemia 2017-08, Vol.31 (8), p.1798-1807
Hauptverfasser:	Liau, W S, Tan, S H, Ngoc, P C T, Wang, C Q, Tergaonkar, V, Feng, H, Gong, Z, Osato, M, Look, A T, Sanda, T
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/63 38 631/136/232/2058 631/67/1990/283/2125 631/67/395 631/67/68 64/116 692/420/755 Aberration Activation Acute lymphoblastic leukemia Acute lymphocytic leukemia Animals Basic Helix-Loop-Helix Transcription Factors - physiology Cancer Research Care and treatment Cell Line, Tumor Critical Care Medicine Differentiation Enhancer Elements, Genetic - physiology GATA-3 protein Genes Genetic transformation GTP-Binding Proteins - genetics Hematology Hematopoietic stem cells Humans Intensive Internal Medicine Leukemia Leukemogenesis Loci Lymphatic leukemia Lymphocytes Lymphocytes T Medicine Medicine & Public Health Membrane Proteins - genetics Mice Mice, Inbred C57BL Multigene Family Oncology original-article Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - etiology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Proteins Proto-Oncogene Proteins - physiology Runx1 protein Stem cells T cell receptors T cells T-Cell Acute Lymphocytic Leukemia Protein 1 Thymocytes Thymus Transcription factors Transcription Factors - physiology Tumorigenesis Zebrafish
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