Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues with a regulated secretory pathway. The impact of CgA depletion on secretory granule formation has been previously demonstrated in cell culture. However, studies linking the structural effects of CgA deficiency wi...

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Veröffentlicht in:	Cell and tissue research 2016-03, Vol.363 (3), p.693-712
Hauptverfasser:	Pasqua, Teresa, Mahata, Sumana, Bandyopadhyay, Gautam K., Biswas, Angshuman, Perkins, Guy A., Sinha-Hikim, Amiya P., Goldstein, David S., Eiden, Lee E., Mahata, Sushil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - metabolism Animals Biomedical and Life Sciences Biomedicine Blotting, Western Catecholamines Catecholamines - metabolism Cellular biology Chromaffin Granules - drug effects Chromaffin Granules - metabolism Chromaffin Granules - ultrastructure Chromogranin A - deficiency Chromogranin A - metabolism Dopamine - metabolism Endocytosis - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Energy Metabolism - drug effects Epinephrine - metabolism Exocytosis - drug effects Glucose - metabolism Glycogen Glycogen - metabolism Golgi Apparatus - drug effects Golgi Apparatus - metabolism Human Genetics Humans Insulin - pharmacology Metabolism Mice, Inbred C57BL Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Molecular Medicine Morphology Norepinephrine - metabolism Proteins Proteomics Regular Article Splanchnic Nerves - drug effects Splanchnic Nerves - metabolism Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism
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