An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness
This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The Co...
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| Veröffentlicht in: | Annals of the American Thoracic Society 2017-06, Vol.14 (6), p.1060-1072 |
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| creator | Summerhill, Eleanor M Hoyle, Gary W Jordt, Sven-Eric Jugg, Bronwen J Martin, James G Matalon, Sadis Patterson, Steven E Prezant, David J Sciuto, Alfred M Svendsen, Erik R White, Carl W Veress, Livia A |
| description | This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectives were to (1) provide a forum to review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents. |
| doi_str_mv | 10.1513/AnnalsATS.201704-297WS |
| format | Article |
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Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>American Thoracic Society (ATS) Journals Online</source><source>Alma/SFX Local Collection</source><creator>Summerhill, Eleanor M ; Hoyle, Gary W ; Jordt, Sven-Eric ; Jugg, Bronwen J ; Martin, James G ; Matalon, Sadis ; Patterson, Steven E ; Prezant, David J ; Sciuto, Alfred M ; Svendsen, Erik R ; White, Carl W ; Veress, Livia A</creator><creatorcontrib>Summerhill, Eleanor M ; Hoyle, Gary W ; Jordt, Sven-Eric ; Jugg, Bronwen J ; Martin, James G ; Matalon, Sadis ; Patterson, Steven E ; Prezant, David J ; Sciuto, Alfred M ; Svendsen, Erik R ; White, Carl W ; Veress, Livia A ; ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly</creatorcontrib><description>This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectives were to (1) provide a forum to review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.</description><identifier>ISSN: 2329-6933</identifier><identifier>EISSN: 2325-6621</identifier><identifier>DOI: 10.1513/AnnalsATS.201704-297WS</identifier><identifier>PMID: 28418689</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Accidents, Occupational ; American Thoracic Society Documents ; Animals ; Biological & chemical weapons ; Chemical Terrorism ; Chlorine ; Collaboration ; Disaster Planning ; Disasters ; Environmental Exposure - adverse effects ; Epidemiology ; FDA approval ; Funding ; Gene expression ; Humans ; Injuries ; Lung - physiopathology ; Lung Injury - chemically induced ; Models, Animal ; Public health ; Rodents ; Signal transduction ; Societies, Medical ; Studies ; Sulfur ; United States</subject><ispartof>Annals of the American Thoracic Society, 2017-06, Vol.14 (6), p.1060-1072</ispartof><rights>Copyright American Thoracic Society Jun 2017</rights><rights>Copyright © 2017 by the American Thoracic Society 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-d39cd75d27b1ecd9ed1d43124399c6aa6a4f603e43bf25423d6297e0508c88493</citedby><cites>FETCH-LOGICAL-c495t-d39cd75d27b1ecd9ed1d43124399c6aa6a4f603e43bf25423d6297e0508c88493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28418689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Summerhill, Eleanor M</creatorcontrib><creatorcontrib>Hoyle, Gary W</creatorcontrib><creatorcontrib>Jordt, Sven-Eric</creatorcontrib><creatorcontrib>Jugg, Bronwen J</creatorcontrib><creatorcontrib>Martin, James G</creatorcontrib><creatorcontrib>Matalon, Sadis</creatorcontrib><creatorcontrib>Patterson, Steven E</creatorcontrib><creatorcontrib>Prezant, David J</creatorcontrib><creatorcontrib>Sciuto, Alfred M</creatorcontrib><creatorcontrib>Svendsen, Erik R</creatorcontrib><creatorcontrib>White, Carl W</creatorcontrib><creatorcontrib>Veress, Livia A</creatorcontrib><creatorcontrib>ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly</creatorcontrib><title>An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness</title><title>Annals of the American Thoracic Society</title><addtitle>Ann Am Thorac Soc</addtitle><description>This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectives were to (1) provide a forum to review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.</description><subject>Accidents, Occupational</subject><subject>American Thoracic Society Documents</subject><subject>Animals</subject><subject>Biological & chemical weapons</subject><subject>Chemical Terrorism</subject><subject>Chlorine</subject><subject>Collaboration</subject><subject>Disaster Planning</subject><subject>Disasters</subject><subject>Environmental Exposure - adverse effects</subject><subject>Epidemiology</subject><subject>FDA approval</subject><subject>Funding</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Injuries</subject><subject>Lung - physiopathology</subject><subject>Lung Injury - chemically induced</subject><subject>Models, Animal</subject><subject>Public health</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Societies, Medical</subject><subject>Studies</subject><subject>Sulfur</subject><subject>United States</subject><issn>2329-6933</issn><issn>2325-6621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpVkd9u0zAUxiMEYtPYK0yWuF1K_C-JuUAKHYxJhSFatEvLtU8alyQOdjKpz7SXxG1HBb6xrXPO9332L0mucDbDHNN3Vd-rNlSr5YxkuMhYSkTxsHyRnBNKeJrnBL88nEWaC0rPkssQtllcJcdlIV4nZ6RkuMxLcZ48VT26r2urrWpR1YG3WvVo1TivtNVo6bSFcYcenP8VGjegHzA4P75H8wa62Nqiu75RrRqti5HQjQ0qjODDDH20rnWbHXI1Wkz9JvZtJ7-7RjfwCK0bOujHfe2bi9foB14NMI1Wh2ukeoO-gjnIf_cwKA-mhxDeJK_q-G64fN4vkp-fP63mX9LF_e3dvFqkmgk-poYKbQpuSLHGoI0Agw2jmDAqhM6VyhWr84wCo-uacEaoyeP_QcazUpclE_Qi-XDUHaZ1B0bHqF61cvC2U34nnbLy_0pvG7lxj5JzIjAto8DbZwHvfk8QRrl1k98zk1hgxjgr8N4mP3Zp70LwUJ8ccCb3nOWJszxylgfOcfDq33ynsb9U6R8RHam6</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Summerhill, Eleanor M</creator><creator>Hoyle, Gary W</creator><creator>Jordt, Sven-Eric</creator><creator>Jugg, Bronwen J</creator><creator>Martin, James G</creator><creator>Matalon, Sadis</creator><creator>Patterson, Steven E</creator><creator>Prezant, David J</creator><creator>Sciuto, Alfred M</creator><creator>Svendsen, Erik R</creator><creator>White, Carl W</creator><creator>Veress, Livia A</creator><general>American Thoracic Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>201706</creationdate><title>An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. 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Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectives were to (1) provide a forum to review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. 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| identifier | ISSN: 2329-6933 |
| ispartof | Annals of the American Thoracic Society, 2017-06, Vol.14 (6), p.1060-1072 |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Accidents, Occupational American Thoracic Society Documents Animals Biological & chemical weapons Chemical Terrorism Chlorine Collaboration Disaster Planning Disasters Environmental Exposure - adverse effects Epidemiology FDA approval Funding Gene expression Humans Injuries Lung - physiopathology Lung Injury - chemically induced Models, Animal Public health Rodents Signal transduction Societies, Medical Studies Sulfur United States |
| title | An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness |
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