Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer

β-catenin is a key signal transducer in the canonical WNT pathway and is negatively regulated by ubiquitin-dependent proteolysis. Through screening of various deubiquitinating enzymes (DUBs), we identified ubiquitin specific protease 4 (USP4) as a candidate for β-catenin-specific DUB. The effects of...

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Veröffentlicht in:	Molecular oncology 2015-11, Vol.9 (9), p.1834-1851
Hauptverfasser:	Yun, Sun-Il, Kim, Hyeon Ho, Yoon, Jung Hwan, Park, Won Sang, Hahn, Myong-Joon, Kim, Hee Cheol, Chung, Chin Ha, Kim, Kyeong Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - metabolism Cancer Catenin Cell growth Cell Movement Colon - metabolism Colon - pathology Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Embryos Enzymes HCT116 Cells Humans Kinases Localization Mutation Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Nuclear transport Pathogenesis Proteinase Proteins Proteolysis Rectum - metabolism Rectum - pathology RNA Interference RNA, Small Interfering - genetics Stem cells Transcription Ubiquitin Ubiquitin specific protease 4 (USP4) Ubiquitin Thiolesterase - analysis Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitin-Specific Proteases Ubiquitination Wnt protein Wnt Proteins - metabolism Wnt Signaling Pathway β-catenin
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