Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti-angiogenic drug resistance?

Angiogenesis is a pivotal process for growth, invasion and spread of the majority of solid tumors including melanoma. Anti-angiogenic agents have not been systematically tested in patients with advanced melanoma. Clinical efficacy of angiogenesis inhibitors targeting endothelial cells has not been a...

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Veröffentlicht in:	Molecular oncology 2011-04, Vol.5 (2), p.137-149
Hauptverfasser:	Helfrich, Iris, Schadendorf, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis inhibitors Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals anti-Angiogenic therapy Blood Vessels - drug effects Blood Vessels - pathology Cell growth Chemotherapy Clinical trials Drug resistance Drug Resistance, Neoplasm Endothelial cells Genotype & phenotype Humans Hypoxia Kinases Maturation Medical prognosis Medical research Melanoma Melanoma - blood supply Melanoma - drug therapy Melanoma - pathology Metabolism Metastasis Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Nitric oxide Pericytes Pericytes - drug effects Pericytes - pathology Phenotypes Review Reviews Skin cancer Smooth muscle Solid tumors Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factors - antagonists & inhibitors Vessel maturation
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