MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S
Stage 4 neuroblastoma (NB) are heterogeneous regarding their clinical presentations and behavior. Indeed infants (stage 4S and non-stage 4S of age 365 days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and...
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| Veröffentlicht in: | Molecular oncology 2008-10, Vol.2 (3), p.261-271 |
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| creator | Bénard, Jean Raguénez, Gilda Kauffmann, Audrey Valent, Alexander Ripoche, Hugues Joulin, Virginie Job, Bastien Danglot, Gisèle Cantais, Sabrina Robert, Thomas Terrier-Lacombe, Marie-José Chassevent, Agnès Koscielny, Serge Fischer, Matthias Berthold, Frank Lipinski, Marc Tursz, Thomas Dessen, Philippe Lazar, Vladimir Valteau-Couanet, Dominique |
| description | Stage 4 neuroblastoma (NB) are heterogeneous regarding their clinical presentations and behavior. Indeed infants (stage 4S and non-stage 4S of age 365
days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and (ii) finding a stage 4S NB signature. Differential genome and transcriptome analyses of a learning set of
MYCN-non amplified stage 4 NB tumors at diagnosis (
n
=
29 tumors including 12 stage 4S) were performed using 1Mb BAC microarrays and
Agilent 22K probes oligo-microarrays. mRNA chips data following filtering yielded informative genes before supervised hierarchical clustering to identify relationship among tumor samples. After confirmation by quantitative RT-PCR, a stage 4S NB's gene cluster was obtained and submitted to a validation set (
n
=
22 tumors). Genomic abnormalities of infant's tumors (whole chromosomes gains or loss) differ radically from that of children (intra-chromosomal rearrangements) but could not discriminate infants with 4S from those without this presentation. In contrast, differential gene expression by looking at both individual genes and whole biological pathways leads to a molecular stage 4S NB portrait which provides new biological clues about this fascinating entity. |
| doi_str_mv | 10.1016/j.molonc.2008.07.002 |
| format | Article |
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days at diagnosis) show regression contrasting with progression in children (>365
days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and (ii) finding a stage 4S NB signature. Differential genome and transcriptome analyses of a learning set of
MYCN-non amplified stage 4 NB tumors at diagnosis (
n
=
29 tumors including 12 stage 4S) were performed using 1Mb BAC microarrays and
Agilent 22K probes oligo-microarrays. mRNA chips data following filtering yielded informative genes before supervised hierarchical clustering to identify relationship among tumor samples. After confirmation by quantitative RT-PCR, a stage 4S NB's gene cluster was obtained and submitted to a validation set (
n
=
22 tumors). Genomic abnormalities of infant's tumors (whole chromosomes gains or loss) differ radically from that of children (intra-chromosomal rearrangements) but could not discriminate infants with 4S from those without this presentation. In contrast, differential gene expression by looking at both individual genes and whole biological pathways leads to a molecular stage 4S NB portrait which provides new biological clues about this fascinating entity.</description><identifier>ISSN: 1574-7891</identifier><identifier>EISSN: 1878-0261</identifier><identifier>DOI: 10.1016/j.molonc.2008.07.002</identifier><identifier>PMID: 19383347</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Age ; Age Factors ; Artificial Intelligence ; Bone marrow ; Child, Preschool ; Children ; Chromosome rearrangements ; Deoxyribonucleic acid ; Diagnosis ; Disease ; DNA ; DNA microarrays ; DNA probes ; Experiments ; Female ; Gene expression ; Gene Expression Profiling - methods ; Genomes ; Genomics ; Humans ; Infant ; Infants ; Learning set ; Male ; Metastases ; Metastasis ; Metastatic neuroblastoma ; Molecular Diagnostic Techniques ; Molecular signature ; N-Myc Proto-Oncogene Protein ; Neoplasm Metastasis - genetics ; Neoplasm Metastasis - pathology ; Neuroblastoma ; Neuroblastoma - genetics ; Neuroblastoma - pathology ; Nuclear Proteins ; Oncogene Proteins ; Patients ; Prognosis ; Remission, Spontaneous ; Software ; Stage 4S ; Tumors</subject><ispartof>Molecular oncology, 2008-10, Vol.2 (3), p.261-271</ispartof><rights>2008 Federation of European Biochemical Societies</rights><rights>2008. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5761-21f51b14609c0aeff1b690eb9dac51c51cdcb51874c7f774615c45134e4c92ce3</citedby><cites>FETCH-LOGICAL-c5761-21f51b14609c0aeff1b690eb9dac51c51cdcb51874c7f774615c45134e4c92ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527812/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1574789108000926$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,3537,11541,27901,27902,45550,45551,46027,46451,53766,53768,65534</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.molonc.2008.07.002$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19383347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bénard, Jean</creatorcontrib><creatorcontrib>Raguénez, Gilda</creatorcontrib><creatorcontrib>Kauffmann, Audrey</creatorcontrib><creatorcontrib>Valent, Alexander</creatorcontrib><creatorcontrib>Ripoche, Hugues</creatorcontrib><creatorcontrib>Joulin, Virginie</creatorcontrib><creatorcontrib>Job, Bastien</creatorcontrib><creatorcontrib>Danglot, Gisèle</creatorcontrib><creatorcontrib>Cantais, Sabrina</creatorcontrib><creatorcontrib>Robert, Thomas</creatorcontrib><creatorcontrib>Terrier-Lacombe, Marie-José</creatorcontrib><creatorcontrib>Chassevent, Agnès</creatorcontrib><creatorcontrib>Koscielny, Serge</creatorcontrib><creatorcontrib>Fischer, Matthias</creatorcontrib><creatorcontrib>Berthold, Frank</creatorcontrib><creatorcontrib>Lipinski, Marc</creatorcontrib><creatorcontrib>Tursz, Thomas</creatorcontrib><creatorcontrib>Dessen, Philippe</creatorcontrib><creatorcontrib>Lazar, Vladimir</creatorcontrib><creatorcontrib>Valteau-Couanet, Dominique</creatorcontrib><title>MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S</title><title>Molecular oncology</title><addtitle>Mol Oncol</addtitle><description>Stage 4 neuroblastoma (NB) are heterogeneous regarding their clinical presentations and behavior. Indeed infants (stage 4S and non-stage 4S of age <365
days at diagnosis) show regression contrasting with progression in children (>365
days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and (ii) finding a stage 4S NB signature. Differential genome and transcriptome analyses of a learning set of
MYCN-non amplified stage 4 NB tumors at diagnosis (
n
=
29 tumors including 12 stage 4S) were performed using 1Mb BAC microarrays and
Agilent 22K probes oligo-microarrays. mRNA chips data following filtering yielded informative genes before supervised hierarchical clustering to identify relationship among tumor samples. After confirmation by quantitative RT-PCR, a stage 4S NB's gene cluster was obtained and submitted to a validation set (
n
=
22 tumors). Genomic abnormalities of infant's tumors (whole chromosomes gains or loss) differ radically from that of children (intra-chromosomal rearrangements) but could not discriminate infants with 4S from those without this presentation. In contrast, differential gene expression by looking at both individual genes and whole biological pathways leads to a molecular stage 4S NB portrait which provides new biological clues about this fascinating entity.</description><subject>Age</subject><subject>Age Factors</subject><subject>Artificial Intelligence</subject><subject>Bone marrow</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chromosome rearrangements</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>DNA</subject><subject>DNA microarrays</subject><subject>DNA probes</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Learning set</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Metastatic neuroblastoma</subject><subject>Molecular Diagnostic Techniques</subject><subject>Molecular signature</subject><subject>N-Myc Proto-Oncogene Protein</subject><subject>Neoplasm Metastasis - genetics</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - pathology</subject><subject>Nuclear Proteins</subject><subject>Oncogene Proteins</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Remission, Spontaneous</subject><subject>Software</subject><subject>Stage 4S</subject><subject>Tumors</subject><issn>1574-7891</issn><issn>1878-0261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNUl2L1DAULaK46-o_EAkIvnXMTZOm8UFZBr9g131QH3wKaXo7m6FNukm7y4I_3gwzuOqDCoHkknMP59x7iuIp0BVQqF9uV2MYgrcrRmmzonJFKbtXHEMjm5KyGu7nt5C8lI2Co-JRSltKRa1q9bA4AlU1VcXlcfH9_Nv6U-mDL804Da532JERZ5NmMztLPC4xtEMuw2jIjZsvySaEjkwxbHxILhHjO5Km4GfjMSyJRNxETMkF_4qckiwR7TKYSKYQ52jcTEJPMvkGCf_8uHjQmyHhk8N9Unx99_bL-kN5dvH-4_r0rLRC1lAy6AW0wGuqLDXY99DWimKrOmMF7E5nW5GNcyt7KXkNwnIBFUduFbNYnRSv97zT0o7YWfRZyqCn6EYTb3UwTv_-492l3oRrLQSTDbBM8OJAEMPVgmnWo0sWh2FvWte1BODVv4GgBBWNaDLw-R_AbViiz1PQjCkFsmlgh-J7lI0hpYj9T81A9S4Feqv3KdC7FGgqdU5Bbnv2q9-7psPaM-DNHnDjBrz9L1J9fnHGdjWrcrjuRop5b9cOo07WobfYuYh21l1wf9f4A8PJ22w</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Bénard, Jean</creator><creator>Raguénez, Gilda</creator><creator>Kauffmann, Audrey</creator><creator>Valent, Alexander</creator><creator>Ripoche, Hugues</creator><creator>Joulin, Virginie</creator><creator>Job, Bastien</creator><creator>Danglot, Gisèle</creator><creator>Cantais, Sabrina</creator><creator>Robert, Thomas</creator><creator>Terrier-Lacombe, Marie-José</creator><creator>Chassevent, Agnès</creator><creator>Koscielny, Serge</creator><creator>Fischer, Matthias</creator><creator>Berthold, Frank</creator><creator>Lipinski, Marc</creator><creator>Tursz, Thomas</creator><creator>Dessen, Philippe</creator><creator>Lazar, Vladimir</creator><creator>Valteau-Couanet, Dominique</creator><general>Elsevier B.V</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200810</creationdate><title>MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S</title><author>Bénard, Jean ; Raguénez, Gilda ; Kauffmann, Audrey ; Valent, Alexander ; Ripoche, Hugues ; Joulin, Virginie ; Job, Bastien ; Danglot, Gisèle ; Cantais, Sabrina ; Robert, Thomas ; Terrier-Lacombe, Marie-José ; Chassevent, Agnès ; Koscielny, Serge ; Fischer, Matthias ; Berthold, Frank ; Lipinski, Marc ; Tursz, Thomas ; Dessen, Philippe ; Lazar, Vladimir ; Valteau-Couanet, Dominique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5761-21f51b14609c0aeff1b690eb9dac51c51cdcb51874c7f774615c45134e4c92ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Artificial Intelligence</topic><topic>Bone marrow</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Chromosome rearrangements</topic><topic>Deoxyribonucleic acid</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>DNA</topic><topic>DNA microarrays</topic><topic>DNA probes</topic><topic>Experiments</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Learning set</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Metastatic neuroblastoma</topic><topic>Molecular Diagnostic Techniques</topic><topic>Molecular signature</topic><topic>N-Myc Proto-Oncogene Protein</topic><topic>Neoplasm Metastasis - genetics</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - pathology</topic><topic>Nuclear Proteins</topic><topic>Oncogene Proteins</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Remission, Spontaneous</topic><topic>Software</topic><topic>Stage 4S</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bénard, Jean</creatorcontrib><creatorcontrib>Raguénez, Gilda</creatorcontrib><creatorcontrib>Kauffmann, Audrey</creatorcontrib><creatorcontrib>Valent, Alexander</creatorcontrib><creatorcontrib>Ripoche, Hugues</creatorcontrib><creatorcontrib>Joulin, Virginie</creatorcontrib><creatorcontrib>Job, Bastien</creatorcontrib><creatorcontrib>Danglot, Gisèle</creatorcontrib><creatorcontrib>Cantais, Sabrina</creatorcontrib><creatorcontrib>Robert, Thomas</creatorcontrib><creatorcontrib>Terrier-Lacombe, Marie-José</creatorcontrib><creatorcontrib>Chassevent, Agnès</creatorcontrib><creatorcontrib>Koscielny, Serge</creatorcontrib><creatorcontrib>Fischer, Matthias</creatorcontrib><creatorcontrib>Berthold, Frank</creatorcontrib><creatorcontrib>Lipinski, Marc</creatorcontrib><creatorcontrib>Tursz, Thomas</creatorcontrib><creatorcontrib>Dessen, Philippe</creatorcontrib><creatorcontrib>Lazar, Vladimir</creatorcontrib><creatorcontrib>Valteau-Couanet, Dominique</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bénard, Jean</au><au>Raguénez, Gilda</au><au>Kauffmann, Audrey</au><au>Valent, Alexander</au><au>Ripoche, Hugues</au><au>Joulin, Virginie</au><au>Job, Bastien</au><au>Danglot, Gisèle</au><au>Cantais, Sabrina</au><au>Robert, Thomas</au><au>Terrier-Lacombe, Marie-José</au><au>Chassevent, Agnès</au><au>Koscielny, Serge</au><au>Fischer, Matthias</au><au>Berthold, Frank</au><au>Lipinski, Marc</au><au>Tursz, Thomas</au><au>Dessen, Philippe</au><au>Lazar, Vladimir</au><au>Valteau-Couanet, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S</atitle><jtitle>Molecular oncology</jtitle><addtitle>Mol Oncol</addtitle><date>2008-10</date><risdate>2008</risdate><volume>2</volume><issue>3</issue><spage>261</spage><epage>271</epage><pages>261-271</pages><issn>1574-7891</issn><eissn>1878-0261</eissn><abstract>Stage 4 neuroblastoma (NB) are heterogeneous regarding their clinical presentations and behavior. Indeed infants (stage 4S and non-stage 4S of age <365
days at diagnosis) show regression contrasting with progression in children (>365
days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and (ii) finding a stage 4S NB signature. Differential genome and transcriptome analyses of a learning set of
MYCN-non amplified stage 4 NB tumors at diagnosis (
n
=
29 tumors including 12 stage 4S) were performed using 1Mb BAC microarrays and
Agilent 22K probes oligo-microarrays. mRNA chips data following filtering yielded informative genes before supervised hierarchical clustering to identify relationship among tumor samples. After confirmation by quantitative RT-PCR, a stage 4S NB's gene cluster was obtained and submitted to a validation set (
n
=
22 tumors). Genomic abnormalities of infant's tumors (whole chromosomes gains or loss) differ radically from that of children (intra-chromosomal rearrangements) but could not discriminate infants with 4S from those without this presentation. In contrast, differential gene expression by looking at both individual genes and whole biological pathways leads to a molecular stage 4S NB portrait which provides new biological clues about this fascinating entity.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>19383347</pmid><doi>10.1016/j.molonc.2008.07.002</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access |
| subjects | Age Age Factors Artificial Intelligence Bone marrow Child, Preschool Children Chromosome rearrangements Deoxyribonucleic acid Diagnosis Disease DNA DNA microarrays DNA probes Experiments Female Gene expression Gene Expression Profiling - methods Genomes Genomics Humans Infant Infants Learning set Male Metastases Metastasis Metastatic neuroblastoma Molecular Diagnostic Techniques Molecular signature N-Myc Proto-Oncogene Protein Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Nuclear Proteins Oncogene Proteins Patients Prognosis Remission, Spontaneous Software Stage 4S Tumors |
| title | MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S |
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