Comparison of three cell-based drug screening platforms for HSV-1 infection

Acyclovir (ACV) and its derivatives have been highly effective for treating recurrent, lytic infections with Herpes Simplex Virus, type 1 (HSV-1), but searches for additional antiviral drugs are motivated by recent reports of resistance to ACV, particularly among immunocompromised patients. In addit...

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Veröffentlicht in:	Antiviral research 2017-06, Vol.142, p.136-140
Hauptverfasser:	D'Aiuto, Leonardo, Williamson, Kelly, Dimitrion, Peter, McNulty, James, Brown, Carla E., Dokuburra, Chanti Babu, Nielsen, Alexander J., Lin, Wen Jing, Piazza, Paolo, Schurdak, Mark E., Wood, Joel, Yolken, Robert H., Kinchington, Paul R., Bloom, David C., Nimgaonkar, Vishwajit L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - toxicity Animals Antiviral Agents - toxicity Central Nervous System - drug effects Chlorocebus aethiops Drug Evaluation, Preclinical Drug Resistance, Viral - drug effects Herpes Simplex - drug therapy Herpes Simplex - virology Herpesvirus 1, Human - drug effects Humans Immunocompromised Host - drug effects Induced Pluripotent Stem Cells - drug effects Neurons - drug effects Pluripotent Stem Cells - drug effects Vero Cells - drug effects
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