Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study
Background. Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovag...
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| Veröffentlicht in: | BioMed research international 2017-01, Vol.2017 (2017), p.1-8 |
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| creator | Nappi, Carmine Morra, Ilaria Giampaolino, Pierluigi Lavitola, Giada De Rosa, Nicoletta Bifulco, Giuseppe |
| description | Background. Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. Materials and Methods. Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24). Results. After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly. Conclusion. Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors. |
| doi_str_mv | 10.1155/2017/7513610 |
| format | Article |
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Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. Materials and Methods. Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24). Results. After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly. Conclusion. Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/7513610</identifier><identifier>PMID: 28781968</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Breast cancer ; Cancer Survivors ; Cancer therapies ; Cervical cancer ; Clinical Study ; Drug therapy ; Female ; Gynecology ; Health aspects ; Health risk assessment ; Health Status ; Humans ; Middle Aged ; Patient outcomes ; Patients ; Prospective Studies ; Quality of Life ; Questionnaires ; Radiation therapy ; Sexual Behavior ; Studies ; Tamoxifen - adverse effects ; Tamoxifen - analogs & derivatives ; Tamoxifen - therapeutic use ; Uterine Cervical Neoplasms - drug therapy ; Uterine Cervical Neoplasms - physiopathology ; Vagina - pathology ; Womens health</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-8</ispartof><rights>Copyright © 2017 Nicoletta De Rosa et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Nicoletta De Rosa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Nicoletta De Rosa et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-2ffa7993e3e72ba602f6dd71acdd59eede3164019d5d84f7b6cc0aef07b9c7513</citedby><cites>FETCH-LOGICAL-c499t-2ffa7993e3e72ba602f6dd71acdd59eede3164019d5d84f7b6cc0aef07b9c7513</cites><orcidid>0000-0003-4759-5243</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525090/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525090/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28781968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lim, Myong Cheol</contributor><creatorcontrib>Nappi, Carmine</creatorcontrib><creatorcontrib>Morra, Ilaria</creatorcontrib><creatorcontrib>Giampaolino, Pierluigi</creatorcontrib><creatorcontrib>Lavitola, Giada</creatorcontrib><creatorcontrib>De Rosa, Nicoletta</creatorcontrib><creatorcontrib>Bifulco, Giuseppe</creatorcontrib><title>Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. Materials and Methods. Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24). Results. After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly. Conclusion. Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.</description><subject>Breast cancer</subject><subject>Cancer Survivors</subject><subject>Cancer therapies</subject><subject>Cervical cancer</subject><subject>Clinical Study</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health Status</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Radiation therapy</subject><subject>Sexual Behavior</subject><subject>Studies</subject><subject>Tamoxifen - adverse effects</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - therapeutic use</subject><subject>Uterine Cervical Neoplasms - drug therapy</subject><subject>Uterine Cervical Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nappi, Carmine</au><au>Morra, Ilaria</au><au>Giampaolino, Pierluigi</au><au>Lavitola, Giada</au><au>De Rosa, Nicoletta</au><au>Bifulco, Giuseppe</au><au>Lim, Myong Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. Materials and Methods. Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24). Results. After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly. Conclusion. Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28781968</pmid><doi>10.1155/2017/7513610</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4759-5243</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Breast cancer Cancer Survivors Cancer therapies Cervical cancer Clinical Study Drug therapy Female Gynecology Health aspects Health risk assessment Health Status Humans Middle Aged Patient outcomes Patients Prospective Studies Quality of Life Questionnaires Radiation therapy Sexual Behavior Studies Tamoxifen - adverse effects Tamoxifen - analogs & derivatives Tamoxifen - therapeutic use Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - physiopathology Vagina - pathology Womens health |
| title | Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study |
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