Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein

Multidrug transporters are ubiquitous efflux pumps that provide cells with defense against various toxic compounds. In bacteria, which typically harbor numerous multidrug transporter genes, the majority function as secondary multidrug/proton antiporters. Proton-coupled secondary transport is a funda...

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Veröffentlicht in:	Molecular cell 2012-09, Vol.47 (5), p.777-787
Hauptverfasser:	Fluman, Nir, Ryan, Christopher M., Whitelegge, Julian P., Bibi, Eitan
Format:	Artikel
Sprache:	eng
Schlagworte:	antiporters bacteria Dicyclohexylcarbodiimide - pharmacology Escherichia coli - cytology Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism genes Hydrogen-Ion Concentration Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism Models, Molecular Onium Compounds - antagonists & inhibitors Onium Compounds - chemistry Onium Compounds - pharmacology Organophosphorus Compounds - antagonists & inhibitors Organophosphorus Compounds - chemistry Organophosphorus Compounds - pharmacology protons Pyronine - pharmacology toxicity
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