EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation

In multiple myeloma, osteolytic lesions rarely heal because of persistent suppressed osteoblast differentiation resulting in a high fracture risk. Herein, chromatin immunoprecipitation analyses reveal that multiple myeloma cells induce repressive epigenetic histone changes at the locus that prevent...

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Veröffentlicht in:	Molecular cancer research 2017-04, Vol.15 (4), p.405-417
Hauptverfasser:	Adamik, Juraj, Jin, Shunqian, Sun, Quanhong, Zhang, Peng, Weiss, Kurt R, Anderson, Judith L, Silbermann, Rebecca, Roodman, G David, Galson, Deborah L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Architecture Biocompatibility Biomedical materials Cancer Cbfa-1 protein Cell Differentiation - drug effects Cell Line, Tumor Chromatin Coculture Techniques Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Differentiation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Enhancer of Zeste Homolog 2 Protein - metabolism Epigenesis, Genetic Epigenetics Gene expression Glial stem cells Histone Deacetylase 1 - antagonists & inhibitors Histone Deacetylase 1 - metabolism Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylase Inhibitors - pharmacology Humans Immunoprecipitation Indoles - administration & dosage Indoles - pharmacology Inhibition Lesions Mice Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - metabolism Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteolysis Osteoprogenitor cells Plasma Promoter Regions, Genetic Pyridones - administration & dosage Pyridones - pharmacology Transcription Transcription Factors - genetics Transcription Factors - metabolism Tumor necrosis factor-α
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