$Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes$

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

In this study, targeted sequencing to screen 50 multidrug refractory multiple myeloma (rMM) patients was performed by using the Multiple Myeloma Mutation Panel. Patients were pretreated with both immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs), and 88%, 78%, and 68% were refractory to...

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Veröffentlicht in:	Blood 2016-09, Vol.128 (9), p.1226-1233
Hauptverfasser:	Kortüm, K.Martin, Mai, Elias K., Hanafiah, Nur H., Shi, Chang-Xi, Zhu, Yuan-Xiao, Bruins, Laura, Barrio, Santiago, Jedlowski, Patrick, Merz, Maximilian, Xu, Jing, Stewart, Robert A., Andrulis, Mindaugas, Jauch, Anna, Hillengass, Jens, Goldschmidt, Hartmut, Bergsagel, P.Leif, Braggio, Esteban, Stewart, A.Keith, Raab, Marc S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Female GTP Phosphohydrolases - genetics High-Throughput Nucleotide Sequencing Humans Lymphoid Neoplasia Male Membrane Proteins - genetics Middle Aged Multiple Myeloma - drug therapy Multiple Myeloma - genetics Mutation Peptide Hydrolases - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Signal Transduction - drug effects Signal Transduction - genetics Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases
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