DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7

DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (I...

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Veröffentlicht in:	Blood 2016-09, Vol.128 (9), p.1214-1225
Hauptverfasser:	Gkotzamanidou, Maria, Terpos, Evangelos, Bamia, Christina, Munshi, Nikhil C., Dimopoulos, Meletios A., Souliotis, Vassilis L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis - drug effects Apoptosis - immunology Bone Marrow Cells - immunology Bone Marrow Cells - pathology Cell Line, Tumor Disease-Free Survival DNA Repair - immunology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - immunology Female Humans Lymphoid Neoplasia Male Melphalan - pharmacology Middle Aged Multiple Myeloma - immunology Multiple Myeloma - pathology Plasma Cells - immunology Plasma Cells - pathology Survival Rate
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