Role of Primary Cilia in Odontogenesis
Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance...
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Veröffentlicht in: | Journal of Dental Research 2017-08, Vol.96 (9), p.965-974 |
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description | Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies. |
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Kunova ; Dosedelova, H. ; Krejci, P. ; Buchtova, M.</creator><creatorcontrib>Hampl, M. ; Cela, P. ; Szabo-Rogers, H.L. ; Bosakova, M. Kunova ; Dosedelova, H. ; Krejci, P. ; Buchtova, M.</creatorcontrib><description>Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/0022034517713688</identifier><identifier>PMID: 28605602</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Bardet-Biedl syndrome ; Cell differentiation ; Cell Differentiation - physiology ; Chemical stimuli ; Cilia ; Cilia - physiology ; Dental enamel ; Dentin ; Dentistry ; Developmental stages ; Dysostosis ; Dysplasia ; Ellis-van Creveld syndrome ; Enamel ; Epithelium ; Homeostasis ; Humans ; Hypoplasia ; Kidneys ; Localization ; Mammalian cells ; Maxillofacial Development - physiology ; Mesenchyme ; Microscopy ; Morphogenesis ; Mutation ; Odontogenesis ; Odontogenesis - physiology ; Phenotypes ; Proteins ; Reviews ; Signal transduction ; Signal Transduction - physiology ; Supernumerary ; Teeth</subject><ispartof>Journal of Dental Research, 2017-08, Vol.96 (9), p.965-974</ispartof><rights>International & American Associations for Dental Research 2017</rights><rights>International & American Associations for Dental Research 2017 2017 International & American Associations for Dental Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-29aa5880cb8c39737e73d282647ec5652afa12def80bc871c36192971f77d7a43</citedby><cites>FETCH-LOGICAL-c528t-29aa5880cb8c39737e73d282647ec5652afa12def80bc871c36192971f77d7a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0022034517713688$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0022034517713688$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,313,314,776,780,788,881,21798,27899,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28605602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hampl, M.</creatorcontrib><creatorcontrib>Cela, P.</creatorcontrib><creatorcontrib>Szabo-Rogers, H.L.</creatorcontrib><creatorcontrib>Bosakova, M. Kunova</creatorcontrib><creatorcontrib>Dosedelova, H.</creatorcontrib><creatorcontrib>Krejci, P.</creatorcontrib><creatorcontrib>Buchtova, M.</creatorcontrib><title>Role of Primary Cilia in Odontogenesis</title><title>Journal of Dental Research</title><addtitle>J Dent Res</addtitle><description>Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.</description><subject>Animals</subject><subject>Bardet-Biedl syndrome</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - physiology</subject><subject>Chemical stimuli</subject><subject>Cilia</subject><subject>Cilia - physiology</subject><subject>Dental enamel</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Developmental stages</subject><subject>Dysostosis</subject><subject>Dysplasia</subject><subject>Ellis-van Creveld syndrome</subject><subject>Enamel</subject><subject>Epithelium</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypoplasia</subject><subject>Kidneys</subject><subject>Localization</subject><subject>Mammalian cells</subject><subject>Maxillofacial Development - physiology</subject><subject>Mesenchyme</subject><subject>Microscopy</subject><subject>Morphogenesis</subject><subject>Mutation</subject><subject>Odontogenesis</subject><subject>Odontogenesis - physiology</subject><subject>Phenotypes</subject><subject>Proteins</subject><subject>Reviews</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>Supernumerary</subject><subject>Teeth</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1LAzEQxYMotlbvnmRBEC-rk2SzSS6CFL9AqIieQ5rN1pTtpm52Bf97U7ZWLXiawPvNmzcZhI4xXGDM-SUAIUAzFt-Y5kLsoCFmWZYCk3gXDVdyutIH6CCEOQCWRNB9NCAiB5YDGaKzZ1_ZxJfJU-MWuvlMxq5yOnF1Mil83fqZrW1w4RDtlboK9mhdR-j19uZlfJ8-Tu4extePqWFEtCmRWjMhwEyFoZJTbjktiCB5xq1hOSO61JgUthQwNYJjQ_MYSXJccl5wndERuup9l910YQtj67bRlVr24ZTXTv1VavemZv5DMUYyQlk0OF8bNP69s6FVCxeMrSpdW98FhSVIApxRGdHTLXTuu6aO6ylCAZgAQXikoKdM40NobLkJg0GtjqC2jxBbTn4vsWn4_vUIpD0Q9Mz-TP3X8AsmJYwy</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Hampl, M.</creator><creator>Cela, P.</creator><creator>Szabo-Rogers, H.L.</creator><creator>Bosakova, M. Kunova</creator><creator>Dosedelova, H.</creator><creator>Krejci, P.</creator><creator>Buchtova, M.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Role of Primary Cilia in Odontogenesis</title><author>Hampl, M. ; Cela, P. ; Szabo-Rogers, H.L. ; Bosakova, M. Kunova ; Dosedelova, H. ; Krejci, P. ; Buchtova, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-29aa5880cb8c39737e73d282647ec5652afa12def80bc871c36192971f77d7a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Bardet-Biedl syndrome</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - physiology</topic><topic>Chemical stimuli</topic><topic>Cilia</topic><topic>Cilia - physiology</topic><topic>Dental enamel</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Developmental stages</topic><topic>Dysostosis</topic><topic>Dysplasia</topic><topic>Ellis-van Creveld syndrome</topic><topic>Enamel</topic><topic>Epithelium</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypoplasia</topic><topic>Kidneys</topic><topic>Localization</topic><topic>Mammalian cells</topic><topic>Maxillofacial Development - physiology</topic><topic>Mesenchyme</topic><topic>Microscopy</topic><topic>Morphogenesis</topic><topic>Mutation</topic><topic>Odontogenesis</topic><topic>Odontogenesis - physiology</topic><topic>Phenotypes</topic><topic>Proteins</topic><topic>Reviews</topic><topic>Signal transduction</topic><topic>Signal Transduction - physiology</topic><topic>Supernumerary</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hampl, M.</creatorcontrib><creatorcontrib>Cela, P.</creatorcontrib><creatorcontrib>Szabo-Rogers, H.L.</creatorcontrib><creatorcontrib>Bosakova, M. 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Kunova</au><au>Dosedelova, H.</au><au>Krejci, P.</au><au>Buchtova, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Primary Cilia in Odontogenesis</atitle><jtitle>Journal of Dental Research</jtitle><addtitle>J Dent Res</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>96</volume><issue>9</issue><spage>965</spage><epage>974</epage><pages>965-974</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. 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subjects | Animals Bardet-Biedl syndrome Cell differentiation Cell Differentiation - physiology Chemical stimuli Cilia Cilia - physiology Dental enamel Dentin Dentistry Developmental stages Dysostosis Dysplasia Ellis-van Creveld syndrome Enamel Epithelium Homeostasis Humans Hypoplasia Kidneys Localization Mammalian cells Maxillofacial Development - physiology Mesenchyme Microscopy Morphogenesis Mutation Odontogenesis Odontogenesis - physiology Phenotypes Proteins Reviews Signal transduction Signal Transduction - physiology Supernumerary Teeth |
title | Role of Primary Cilia in Odontogenesis |
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