Role of Primary Cilia in Odontogenesis

Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance...

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Veröffentlicht in:Journal of Dental Research 2017-08, Vol.96 (9), p.965-974
Hauptverfasser: Hampl, M., Cela, P., Szabo-Rogers, H.L., Bosakova, M. Kunova, Dosedelova, H., Krejci, P., Buchtova, M.
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container_end_page 974
container_issue 9
container_start_page 965
container_title Journal of Dental Research
container_volume 96
creator Hampl, M.
Cela, P.
Szabo-Rogers, H.L.
Bosakova, M. Kunova
Dosedelova, H.
Krejci, P.
Buchtova, M.
description Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
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As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. 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As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue–producing cells. 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subjects Animals
Bardet-Biedl syndrome
Cell differentiation
Cell Differentiation - physiology
Chemical stimuli
Cilia
Cilia - physiology
Dental enamel
Dentin
Dentistry
Developmental stages
Dysostosis
Dysplasia
Ellis-van Creveld syndrome
Enamel
Epithelium
Homeostasis
Humans
Hypoplasia
Kidneys
Localization
Mammalian cells
Maxillofacial Development - physiology
Mesenchyme
Microscopy
Morphogenesis
Mutation
Odontogenesis
Odontogenesis - physiology
Phenotypes
Proteins
Reviews
Signal transduction
Signal Transduction - physiology
Supernumerary
Teeth
title Role of Primary Cilia in Odontogenesis
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