Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

The induction of a strong cytotoxic T cell response is an important prerequisite for successful immunotherapy against many viral diseases and tumors. Nucleotide vaccines, including mRNA vaccines with their intracellular antigen synthesis, have been shown to be potent activators of a cytotoxic immune...

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Veröffentlicht in:	Nano letters 2017-03, Vol.17 (3), p.1326-1335
Hauptverfasser:	Oberli, Matthias A, Reichmuth, Andreas M, Dorkin, J. Robert, Mitchell, Michael J, Fenton, Owen S, Jaklenec, Ana, Anderson, Daniel G, Langer, Robert, Blankschtein, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cytotoxicity, Immunologic Drug delivery systems Humans Immune systems Immunotherapy Lipids Lipids - chemistry Lymphocytes Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice, Inbred C57BL Nanoparticles - chemistry Nanostructure Ovalbumin - genetics RNA, Messenger - administration & dosage RNA, Messenger - chemistry Tumors Vaccines Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use
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