An Insertion in the Catalytic Trigger Loop Gates the Secondary Channel of RNA Polymerase

Escherichia coli DksA and GreB bind to RNA polymerase (RNAP), reaching inside the secondary channel, with similar affinities but have different cellular functions. DksA destabilizes promoter complexes whereas GreB facilitates RNA cleavage in arrested elongation complexes (ECs). Although the less abu...

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Veröffentlicht in:	Journal of molecular biology 2013-01, Vol.425 (1), p.82-93
Hauptverfasser:	Furman, Ran, Tsodikov, Oleg V., Wolf, Yuri I., Artsimovitch, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence chemistry DksA DNA DNA-directed RNA polymerase DNA-Directed RNA Polymerases DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Elongation Escherichia coli Escherichia coli - chemistry Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - isolation & purification Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial genetics genome Genomes Gre Insertion isolation & purification metabolism Models, Molecular Models, Structural Molecular Sequence Data Promoter Regions, Genetic Promoters Protein Binding Protein Structure, Tertiary RNA RNA Cleavage RNA polymerase RNA, Bacterial RNA, Bacterial - genetics RNA, Bacterial - metabolism secondary channel Sequence Alignment Sequence Deletion Transcription Transcription Elongation, Genetic Transcription Termination, Genetic Transcription, Genetic Transcriptional Elongation Factors Transcriptional Elongation Factors - chemistry Transcriptional Elongation Factors - isolation & purification Transcriptional Elongation Factors - metabolism trigger loop
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