KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively kill tumor cells. TRAIL resistance in cancers is associated with aberrant expression of the key components of the apoptotic program. However, how these components are regulated at the epigenetic level is not understood....

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Veröffentlicht in:	Cell death & disease 2017-06, Vol.8 (6), p.e2897-e2897
Hauptverfasser:	Kurt, Ibrahim Cagri, Sur, Ilknur, Kaya, Ezgi, Cingoz, Ahmet, Kazancioglu, Selena, Kahya, Zeynep, Toparlak, Omer Duhan, Senbabaoglu, Filiz, Kaya, Zeynep, Ozyerli, Ezgi, Karahüseyinoglu, Sercin, Lack, Nathan A, Gümüs, Zeynep H, Onder, Tamer T, Bagci-Onder, Tugba
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38 42/89 631/337/176 631/67/1059/99 631/67/1922 631/80/82/23 82/80 96/2 Antibodies Apoptosis Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Biochemistry Biomedical and Life Sciences Brain cancer Caspase Caspase 7 - genetics Caspase-7 Caspase-8 Cell Biology Cell Culture Cell Line, Tumor Death Deoxyribonucleic acid Derepression DNA DNA Methylation - genetics Enzymes Epigenesis, Genetic - genetics Epigenetics F-Box Proteins - genetics Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques Gene silencing Glioblastoma Glioblastoma - genetics Glioblastoma - pathology Glioblastoma multiforme Histone Code - genetics Humans Immunology Jumonji Domain-Containing Histone Demethylases - genetics Life Sciences Original original-article Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Ribonucleic acid RNA RNA, Small Interfering - genetics Signal transduction TNF-Related Apoptosis-Inducing Ligand - administration & dosage TNF-Related Apoptosis-Inducing Ligand - genetics TRAIL protein Tumor cells Tumor necrosis factor Tumors
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