Ethanol Withdrawal Drives Anxiety-Related Behaviors by Reducing M-type Potassium Channel Activity in the Lateral Habenula

Alcohol use disorders (AUDs) and anxiety disorders (ADs) are often seen concurrently, but their underlying cellular basis is unclear. For unclear reasons, the lateral habenula (LHb), a key brain region involved in the pathophysiology of ADs, becomes hyperactive after ethanol withdrawal. M-type K cha...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2017-08, Vol.42 (9), p.1813-1824
Hauptverfasser:	Kang, Seungwoo, Li, Jing, Zuo, Wanhong, Fu, Rao, Gregor, Danielle, Krnjevic, Kresimir, Bekker, Alex, Ye, Jiang-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Afterhyperpolarization Alcohol use Alcoholic beverages Alcoholics Anxiety Brain Brain slice preparation Channel gating Drinking behavior Ethanol Excitability Firing rate Habenula Inhibition Injection KCNQ2 protein Luteinizing hormone Neurons Original Potassium Potassium channels (voltage-gated) Potassium currents Rats Rodents
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