Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

Pediatric-type follicular lymphoma (PTFL) is a B-cell lymphoma with distinctive clinicopathological features. Recently, recurrent genetic alterations of potential importance for its pathogenesis that disrupt pathways associated with the germinal center reaction (TNFRSF14, IRF8), immune escape (TNFRS...

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Veröffentlicht in:	Blood 2017-07, Vol.130 (3), p.323-327
Hauptverfasser:	Schmidt, Janine, Ramis-Zaldivar, Joan Enric, Nadeu, Ferran, Gonzalez-Farre, Blanca, Navarro, Alba, Egan, Caoimhe, Montes-Mojarro, Ivonne Aidee, Marafioti, Teresa, Cabeçadas, Jose, van der Walt, Jon, Dojcinov, Stefan, Rosenwald, Andreas, Ott, German, Bonzheim, Irina, Fend, Falko, Campo, Elias, Jaffe, Elaine S., Salaverria, Itziar, Quintanilla-Martinez, Leticia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Brief Report Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Child DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Frequency High-Throughput Nucleotide Sequencing Humans Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Lymphoid Neoplasia Lymphoma, Follicular - diagnosis Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Male MAP Kinase Kinase 1 - genetics MAP Kinase Kinase 1 - metabolism Microarray Analysis Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Mutation Phosphorylation Receptors, Tumor Necrosis Factor, Member 14 - genetics Receptors, Tumor Necrosis Factor, Member 14 - metabolism
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