Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron

The iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens. The mechanisms by which hep...

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