Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSNIO, for programmable co-delivery of an immune...

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Veröffentlicht in:	Acta pharmacologica Sinica 2017-06, Vol.38 (6), p.823-834
Hauptverfasser:	Sun, Jing-jing, Chen, Yi-chao, Huang, Yi-xian, Zhao, Wen-chen, Liu, Yan-hua, Venkataramanan, Raman, Lu, Bin-feng, Li, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Cell Proliferation - drug effects Dose-Response Relationship, Drug Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Drug Delivery Systems Drug Screening Assays, Antitumor Female Humans Imidazoles - chemistry Imidazoles - pharmacology Immunization Immunology Internal Medicine Isoindoles - chemistry Isoindoles - pharmacology Medical Microbiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Micelles Molecular Structure Original original-article Oxidation-Reduction Pharmacology/Toxicology Polymers - chemistry Polymers - pharmacology Prodrugs - chemistry Prodrugs - pharmacology Structure-Activity Relationship T-Lymphocytes - drug effects T-Lymphocytes - immunology Tissue Distribution Tumor Cells, Cultured Vaccine 免疫刺激活性化疗药物可编程抑制剂检查点氧化还原反应纳米载体阿霉素
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