Neuromyelitis Optica Spectrum Disorder with Recurrent Intracranial Hemorrhage
The patient was a woman without hypertension who had previously experienced intracranial hemorrhage twice at 48 and 56 years of age. At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquapo...
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| Veröffentlicht in: | Internal Medicine 2017/07/01, Vol.56(13), pp.1729-1732 |
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| container_title | Internal Medicine |
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| creator | Yaguchi, Hiroaki Mito, Yasunori Ohashi, Ikkei Nomura, Taichi Yabe, Ichiro Tajima, Yasutaka |
| description | The patient was a woman without hypertension who had previously experienced intracranial hemorrhage twice at 48 and 56 years of age. At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquaporin 4 (AQP4) antibodies. After 5 months of continuous treatment with prednisolone (15 mg/day), she presented with optic neuritis and intracranial bleeding. A recurrent attack of NMOSD and intracranial hemorrhage were concurrently diagnosed. We herein report a case of NMOSD with recurrent intracranial hemorrhage, which indicates an association between NMOSD and cerebellar vascular dysfunction. |
| doi_str_mv | 10.2169/internalmedicine.56.7889 |
| format | Article |
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At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquaporin 4 (AQP4) antibodies. After 5 months of continuous treatment with prednisolone (15 mg/day), she presented with optic neuritis and intracranial bleeding. A recurrent attack of NMOSD and intracranial hemorrhage were concurrently diagnosed. We herein report a case of NMOSD with recurrent intracranial hemorrhage, which indicates an association between NMOSD and cerebellar vascular dysfunction.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.56.7889</identifier><identifier>PMID: 28674367</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aquaporin 4 ; Aquaporin 4 - immunology ; Autoantibodies - immunology ; brain blood barrier (BBB) ; Brain stem ; Case Report ; Case reports ; Cerebellum ; Female ; Hemorrhage ; Humans ; Internal medicine ; Intracranial Hemorrhages - etiology ; Middle Aged ; Neuritis ; Neuromyelitis ; Neuromyelitis Optica - complications ; Neuromyelitis Optica - drug therapy ; neuromyelitis optica spectrum disorder (NMOSD) ; Optic neuritis ; Prednisolone ; Prednisolone - therapeutic use ; recurrent intracranial hemorrhage</subject><ispartof>Internal Medicine, 2017/07/01, Vol.56(13), pp.1729-1732</ispartof><rights>2017 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><rights>Copyright © 2017 by The Japanese Society of Internal Medicine 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-203fb9f0baa89fc3cebf4a5a691104bb311cbec26db3aee36482a62839e1961d3</citedby><cites>FETCH-LOGICAL-c610t-203fb9f0baa89fc3cebf4a5a691104bb311cbec26db3aee36482a62839e1961d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519480/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519480/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28674367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaguchi, Hiroaki</creatorcontrib><creatorcontrib>Mito, Yasunori</creatorcontrib><creatorcontrib>Ohashi, Ikkei</creatorcontrib><creatorcontrib>Nomura, Taichi</creatorcontrib><creatorcontrib>Yabe, Ichiro</creatorcontrib><creatorcontrib>Tajima, Yasutaka</creatorcontrib><title>Neuromyelitis Optica Spectrum Disorder with Recurrent Intracranial Hemorrhage</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>The patient was a woman without hypertension who had previously experienced intracranial hemorrhage twice at 48 and 56 years of age. At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquaporin 4 (AQP4) antibodies. After 5 months of continuous treatment with prednisolone (15 mg/day), she presented with optic neuritis and intracranial bleeding. A recurrent attack of NMOSD and intracranial hemorrhage were concurrently diagnosed. We herein report a case of NMOSD with recurrent intracranial hemorrhage, which indicates an association between NMOSD and cerebellar vascular dysfunction.</description><subject>Aquaporin 4</subject><subject>Aquaporin 4 - immunology</subject><subject>Autoantibodies - immunology</subject><subject>brain blood barrier (BBB)</subject><subject>Brain stem</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Cerebellum</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Intracranial Hemorrhages - etiology</subject><subject>Middle Aged</subject><subject>Neuritis</subject><subject>Neuromyelitis</subject><subject>Neuromyelitis Optica - complications</subject><subject>Neuromyelitis Optica - drug therapy</subject><subject>neuromyelitis optica spectrum disorder (NMOSD)</subject><subject>Optic neuritis</subject><subject>Prednisolone</subject><subject>Prednisolone - therapeutic use</subject><subject>recurrent intracranial hemorrhage</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v1DAQxS0EokvhK6BIXLhk8Z_EsS9IqIW2UtuVCpytiXfS9SpxFtsB9dvX0S4rWnEZH-Y3b8bvEVIwuuRM6k_OJwwe-gHXzjqPy1ouG6X0C7JgotJlw0X9kiyoZqrkuZyQNzFuKRWq0fw1OeFKNpWQzYLc3OIUxuEBe5dcLFa75CwU33doU5iG4tzFMawxFH9c2hR3aKcQ0KfiyqcANoB30BeXOIwhbOAe35JXHfQR3x3eU_Lz29cfZ5fl9eri6uzLdWklo6nkVHSt7mgLoHRnhcW2q6AGqRmjVdsKxmyLlst1KwBRyEpxkFwJjUxLthan5PNedze12QOL8zm92QU3QHgwIzjztOPdxtyPv01dM10pmgU-HgTC-GvCmMzgosW-B4_jFA3TrFaNElRn9MMzdDtOs_nRcMqqWlRcsUypPWXDGGPA7ngMo2bOzDzPzNTSzJnl0ff_fuY4-DekDKz2wDambPIRgJDD6vG_ykzM9bDiSNoNBINePALDPLfu</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Yaguchi, Hiroaki</creator><creator>Mito, Yasunori</creator><creator>Ohashi, Ikkei</creator><creator>Nomura, Taichi</creator><creator>Yabe, Ichiro</creator><creator>Tajima, Yasutaka</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Neuromyelitis Optica Spectrum Disorder with Recurrent Intracranial Hemorrhage</title><author>Yaguchi, Hiroaki ; Mito, Yasunori ; Ohashi, Ikkei ; Nomura, Taichi ; Yabe, Ichiro ; Tajima, Yasutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-203fb9f0baa89fc3cebf4a5a691104bb311cbec26db3aee36482a62839e1961d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aquaporin 4</topic><topic>Aquaporin 4 - immunology</topic><topic>Autoantibodies - immunology</topic><topic>brain blood barrier (BBB)</topic><topic>Brain stem</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Cerebellum</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Intracranial Hemorrhages - etiology</topic><topic>Middle Aged</topic><topic>Neuritis</topic><topic>Neuromyelitis</topic><topic>Neuromyelitis Optica - complications</topic><topic>Neuromyelitis Optica - drug therapy</topic><topic>neuromyelitis optica spectrum disorder (NMOSD)</topic><topic>Optic neuritis</topic><topic>Prednisolone</topic><topic>Prednisolone - therapeutic use</topic><topic>recurrent intracranial hemorrhage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaguchi, Hiroaki</creatorcontrib><creatorcontrib>Mito, Yasunori</creatorcontrib><creatorcontrib>Ohashi, Ikkei</creatorcontrib><creatorcontrib>Nomura, Taichi</creatorcontrib><creatorcontrib>Yabe, Ichiro</creatorcontrib><creatorcontrib>Tajima, Yasutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaguchi, Hiroaki</au><au>Mito, Yasunori</au><au>Ohashi, Ikkei</au><au>Nomura, Taichi</au><au>Yabe, Ichiro</au><au>Tajima, Yasutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromyelitis Optica Spectrum Disorder with Recurrent Intracranial Hemorrhage</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>56</volume><issue>13</issue><spage>1729</spage><epage>1732</epage><pages>1729-1732</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>The patient was a woman without hypertension who had previously experienced intracranial hemorrhage twice at 48 and 56 years of age. At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquaporin 4 (AQP4) antibodies. After 5 months of continuous treatment with prednisolone (15 mg/day), she presented with optic neuritis and intracranial bleeding. A recurrent attack of NMOSD and intracranial hemorrhage were concurrently diagnosed. We herein report a case of NMOSD with recurrent intracranial hemorrhage, which indicates an association between NMOSD and cerebellar vascular dysfunction.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>28674367</pmid><doi>10.2169/internalmedicine.56.7889</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aquaporin 4 Aquaporin 4 - immunology Autoantibodies - immunology brain blood barrier (BBB) Brain stem Case Report Case reports Cerebellum Female Hemorrhage Humans Internal medicine Intracranial Hemorrhages - etiology Middle Aged Neuritis Neuromyelitis Neuromyelitis Optica - complications Neuromyelitis Optica - drug therapy neuromyelitis optica spectrum disorder (NMOSD) Optic neuritis Prednisolone Prednisolone - therapeutic use recurrent intracranial hemorrhage |
| title | Neuromyelitis Optica Spectrum Disorder with Recurrent Intracranial Hemorrhage |
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