Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells

Substance P (SP) is involved in the proliferation of cholangiocytes in bile duct–ligated (BDL) mice and human cholangiocarcinoma growth by interacting with the neurokinin‐1 receptor (NK‐1R). To identify whether SP regulates liver fibrosis during cholestasis, wild‐type or NK‐1R knockout (NK‐1R–/–) mi...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2017-08, Vol.66 (2), p.528-541
Hauptverfasser:	Wan, Ying, Meng, Fanyin, Wu, Nan, Zhou, Tianhao, Venter, Julie, Francis, Heather, Kennedy, Lindsey, Glaser, Trenton, Bernuzzi, Francesca, Invernizzi, Pietro, Glaser, Shannon, Huang, Qiaobing, Alpini, Gianfranco
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - pathology Animals Apoptosis - physiology Bile Bile ducts Bile Ducts - cytology Biomarkers - metabolism Biopsy, Needle Cell Proliferation Cells, Cultured Cholangiocarcinoma Cholangitis Cholestasis Coding Disease Models, Animal Fibrosis Gene expression Hepatic Stellate Cells - cytology Hepatic Stellate Cells - metabolism Hepatology Humans Immunohistochemistry Liver Liver Cirrhosis - pathology Liver Function Tests Male Mice Mice, Inbred C57BL Mice, Knockout Multidrug resistance Neurokinin Neurokinin NK1 receptors Random Allocation RNA, Messenger - metabolism Rodents Senescence Sensitivity and Specificity Stellate cells Substance P Substance P - metabolism Surgery Tachykinin Tachykinin receptors
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