Characteristic clinical features associated with aggressive posterior retinopathy of prematurity
Purpose To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants. Methods Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 i...
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| Veröffentlicht in: | Eye (London) 2017-06, Vol.31 (6), p.924-930 |
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| creator | Ahn, Y J Hong, K E Yum, H R Lee, J H Kim, K S Youn, Y A Park, S H |
| description | Purpose
To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants.
Methods
Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed and anatomical outcomes were compared according to the severity of ROP and treatment modalities.
Results
The mean gestational age and birth weight at birth in the APROP group were significantly lower than those in the non-APROP group (
P
=0.019,
P |
| doi_str_mv | 10.1038/eye.2017.18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5518835</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4322751419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c549t-1c23bf3c9f82bc341c00283acc29122f00d0da7d4bb505f14208b8a1be67c47c3</originalsourceid><addsrcrecordid>eNqFkc-L1DAYhoMo7uzqybsEvAja8UuatMlFkMFVYcGLgreYpl9nsnSamqQr89-bYdZlFcFTIO_zPfnxEvKMwZpBrd7gAdccWLtm6gFZMdE2lRRSPCQr0BIqzvm3M3Ke0jVACVt4TM644rWopViR75udjdZljD5l76gb_eSdHemANi8RE7UpBedtxp7-9HlH7XZbtpO_QTqHdBwMkUbMfgqzzbsDDQOdI-6P4z4fnpBHgx0TPr1dL8jXy_dfNh-rq88fPm3eXVVOCp0r5njdDbXTg-KdqwVzAFzV1jmuGecDQA-9bXvRdRLkwAQH1SnLOmxaJ1pXX5C3J--8dHvsHU452tHM0e9tPJhgvfkzmfzObMONkZIpVcsieHkriOHHgimbvU8Ox9FOGJZkmGasYVpI_X9UtVy2mmtR0Bd_oddhiVP5iSKERmnQoinUqxPlYkgp4nB3bwbmWLIpJZtjycVd6Of3n3rH_m61AK9PQCrRtMV479B_-H4BJKOz5w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1906890946</pqid></control><display><type>article</type><title>Characteristic clinical features associated with aggressive posterior retinopathy of prematurity</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ahn, Y J ; Hong, K E ; Yum, H R ; Lee, J H ; Kim, K S ; Youn, Y A ; Park, S H</creator><creatorcontrib>Ahn, Y J ; Hong, K E ; Yum, H R ; Lee, J H ; Kim, K S ; Youn, Y A ; Park, S H</creatorcontrib><description>Purpose
To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants.
Methods
Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed and anatomical outcomes were compared according to the severity of ROP and treatment modalities.
Results
The mean gestational age and birth weight at birth in the APROP group were significantly lower than those in the non-APROP group (
P
=0.019,
P
<0.001, respectively). Infants who were born small for their GA developed APROP more frequently than non-APROP patients (
P
<0.001). Chorioamnionitis-positive infants also showed higher incidence rate of APROP (APROP
vs
non-APROP;
P
<0.001 and zone I APROP
vs
posterior zone II APROP;
P
=0.036, respectively). Infants with APROP required heavier laser treatment with a higher retreatment rate compared to infants with non-APROP. Favorable anatomical outcomes were achieved in 95.3% from treatment-requiring non-APROP group, 85.7% from zone I APROP and 84.6% from posterior zone II APROP group.
Conclusion
Intrauterine growth restriction and chorioamnionitis were associated with development of APROP. These findings suggest that perinatal maternal environment inhibiting normal retinal vascular growth
in utero
may contribute to increasing the risk of APROP in premature infants.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2017.18</identifier><identifier>PMID: 28234354</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/3161/3175 ; Angiogenesis Inhibitors - administration & dosage ; Bevacizumab - administration & dosage ; Clinical Study ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intravitreal Injections ; Laboratory Medicine ; Laser Coagulation - methods ; Male ; Medicine ; Medicine & Public Health ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Posterior Eye Segment - diagnostic imaging ; Retinopathy of Prematurity - diagnosis ; Retinopathy of Prematurity - therapy ; Retrospective Studies ; Severity of Illness Index ; Surgery ; Surgical Oncology ; Treatment Outcome ; Ultrasonography</subject><ispartof>Eye (London), 2017-06, Vol.31 (6), p.924-930</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>Copyright Nature Publishing Group Jun 2017</rights><rights>Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature. 2017 Macmillan Publishers Limited, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-1c23bf3c9f82bc341c00283acc29122f00d0da7d4bb505f14208b8a1be67c47c3</citedby><cites>FETCH-LOGICAL-c549t-1c23bf3c9f82bc341c00283acc29122f00d0da7d4bb505f14208b8a1be67c47c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518835/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518835/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28234354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Y J</creatorcontrib><creatorcontrib>Hong, K E</creatorcontrib><creatorcontrib>Yum, H R</creatorcontrib><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kim, K S</creatorcontrib><creatorcontrib>Youn, Y A</creatorcontrib><creatorcontrib>Park, S H</creatorcontrib><title>Characteristic clinical features associated with aggressive posterior retinopathy of prematurity</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants.
Methods
Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed and anatomical outcomes were compared according to the severity of ROP and treatment modalities.
Results
The mean gestational age and birth weight at birth in the APROP group were significantly lower than those in the non-APROP group (
P
=0.019,
P
<0.001, respectively). Infants who were born small for their GA developed APROP more frequently than non-APROP patients (
P
<0.001). Chorioamnionitis-positive infants also showed higher incidence rate of APROP (APROP
vs
non-APROP;
P
<0.001 and zone I APROP
vs
posterior zone II APROP;
P
=0.036, respectively). Infants with APROP required heavier laser treatment with a higher retreatment rate compared to infants with non-APROP. Favorable anatomical outcomes were achieved in 95.3% from treatment-requiring non-APROP group, 85.7% from zone I APROP and 84.6% from posterior zone II APROP group.
Conclusion
Intrauterine growth restriction and chorioamnionitis were associated with development of APROP. These findings suggest that perinatal maternal environment inhibiting normal retinal vascular growth
in utero
may contribute to increasing the risk of APROP in premature infants.</description><subject>692/499</subject><subject>692/699/3161/3175</subject><subject>Angiogenesis Inhibitors - administration & dosage</subject><subject>Bevacizumab - administration & dosage</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intravitreal Injections</subject><subject>Laboratory Medicine</subject><subject>Laser Coagulation - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Posterior Eye Segment - diagnostic imaging</subject><subject>Retinopathy of Prematurity - diagnosis</subject><subject>Retinopathy of Prematurity - therapy</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc-L1DAYhoMo7uzqybsEvAja8UuatMlFkMFVYcGLgreYpl9nsnSamqQr89-bYdZlFcFTIO_zPfnxEvKMwZpBrd7gAdccWLtm6gFZMdE2lRRSPCQr0BIqzvm3M3Ke0jVACVt4TM644rWopViR75udjdZljD5l76gb_eSdHemANi8RE7UpBedtxp7-9HlH7XZbtpO_QTqHdBwMkUbMfgqzzbsDDQOdI-6P4z4fnpBHgx0TPr1dL8jXy_dfNh-rq88fPm3eXVVOCp0r5njdDbXTg-KdqwVzAFzV1jmuGecDQA-9bXvRdRLkwAQH1SnLOmxaJ1pXX5C3J--8dHvsHU452tHM0e9tPJhgvfkzmfzObMONkZIpVcsieHkriOHHgimbvU8Ox9FOGJZkmGasYVpI_X9UtVy2mmtR0Bd_oddhiVP5iSKERmnQoinUqxPlYkgp4nB3bwbmWLIpJZtjycVd6Of3n3rH_m61AK9PQCrRtMV479B_-H4BJKOz5w</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Ahn, Y J</creator><creator>Hong, K E</creator><creator>Yum, H R</creator><creator>Lee, J H</creator><creator>Kim, K S</creator><creator>Youn, Y A</creator><creator>Park, S H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Characteristic clinical features associated with aggressive posterior retinopathy of prematurity</title><author>Ahn, Y J ; Hong, K E ; Yum, H R ; Lee, J H ; Kim, K S ; Youn, Y A ; Park, S H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-1c23bf3c9f82bc341c00283acc29122f00d0da7d4bb505f14208b8a1be67c47c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/499</topic><topic>692/699/3161/3175</topic><topic>Angiogenesis Inhibitors - administration & dosage</topic><topic>Bevacizumab - administration & dosage</topic><topic>Clinical Study</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intravitreal Injections</topic><topic>Laboratory Medicine</topic><topic>Laser Coagulation - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Posterior Eye Segment - diagnostic imaging</topic><topic>Retinopathy of Prematurity - diagnosis</topic><topic>Retinopathy of Prematurity - therapy</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Y J</creatorcontrib><creatorcontrib>Hong, K E</creatorcontrib><creatorcontrib>Yum, H R</creatorcontrib><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kim, K S</creatorcontrib><creatorcontrib>Youn, Y A</creatorcontrib><creatorcontrib>Park, S H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Y J</au><au>Hong, K E</au><au>Yum, H R</au><au>Lee, J H</au><au>Kim, K S</au><au>Youn, Y A</au><au>Park, S H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristic clinical features associated with aggressive posterior retinopathy of prematurity</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>31</volume><issue>6</issue><spage>924</spage><epage>930</epage><pages>924-930</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants.
Methods
Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed and anatomical outcomes were compared according to the severity of ROP and treatment modalities.
Results
The mean gestational age and birth weight at birth in the APROP group were significantly lower than those in the non-APROP group (
P
=0.019,
P
<0.001, respectively). Infants who were born small for their GA developed APROP more frequently than non-APROP patients (
P
<0.001). Chorioamnionitis-positive infants also showed higher incidence rate of APROP (APROP
vs
non-APROP;
P
<0.001 and zone I APROP
vs
posterior zone II APROP;
P
=0.036, respectively). Infants with APROP required heavier laser treatment with a higher retreatment rate compared to infants with non-APROP. Favorable anatomical outcomes were achieved in 95.3% from treatment-requiring non-APROP group, 85.7% from zone I APROP and 84.6% from posterior zone II APROP group.
Conclusion
Intrauterine growth restriction and chorioamnionitis were associated with development of APROP. These findings suggest that perinatal maternal environment inhibiting normal retinal vascular growth
in utero
may contribute to increasing the risk of APROP in premature infants.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28234354</pmid><doi>10.1038/eye.2017.18</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2017-06, Vol.31 (6), p.924-930 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5518835 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 692/499 692/699/3161/3175 Angiogenesis Inhibitors - administration & dosage Bevacizumab - administration & dosage Clinical Study Female Follow-Up Studies Gestational Age Humans Infant Infant, Newborn Infant, Premature Intravitreal Injections Laboratory Medicine Laser Coagulation - methods Male Medicine Medicine & Public Health Ophthalmology Pharmaceutical Sciences/Technology Posterior Eye Segment - diagnostic imaging Retinopathy of Prematurity - diagnosis Retinopathy of Prematurity - therapy Retrospective Studies Severity of Illness Index Surgery Surgical Oncology Treatment Outcome Ultrasonography |
| title | Characteristic clinical features associated with aggressive posterior retinopathy of prematurity |
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