Potential contribution of insecticide exposure and development of obesity and type 2 diabetes

The introduction of insecticides has greatly improved agricultural productivity and human nutrition; however, the wide use of insecticides has also sparked growing concern over their health impacts. Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure. Meanwhile, a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type 2 diabetes. This review summarizes the relationship between insecticide exposure and development of obesity and type 2 diabetes using epidemiological and rodent animal studies, including potential mechanisms. The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type 2 diabetes. •Exposure to insecticides are positively associated with the risk of obesity and type 2 diabetes.•Exposure to insecticides may disturb glucose and lipid metabolisms.•Insecticide may induce oxidative and/or endoplasmic reticulum stresses.