Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties

Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted to specific synapses, but their synaptic functions and mechanistic redundancy are not completely understood. Overexpr...

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Veröffentlicht in:	The Journal of neuroscience 2017-07, Vol.37 (29), p.6816-6836
Hauptverfasser:	Chanda, Soham, Hale, W Dylan, Zhang, Bo, Wernig, Marius, Südhof, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules, Neuronal - metabolism Cells, Cultured Density Excitatory Postsynaptic Potentials - physiology Female Gene Expression Regulation, Developmental - physiology Hippocampus Isoforms Male Membrane Proteins - metabolism Mice Mice, Knockout Nerve Tissue Proteins - metabolism Neural Inhibition - physiology Neurogenesis - physiology Neurons Neurotransmitter receptors Phenotypes Physiological effects Physiology Receptors Redundancy RNA-mediated interference Spine Synapses Synapses - physiology Synaptic density Synaptic transmission Synaptic Transmission - physiology Synaptogenesis
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