Expression of neuronal nicotinic acetylcholine receptor genes in the developing chick visual system
Expression of the neuronal non‐alpha nicotinic acetylcholine receptor (n alpha nAChR) gene is transiently stimulated in the chick optic tectum between embryonic days 7 and 16 with a peak value reached around embryonic day 12. This stimulation takes place at the time when optic nerve axons are invadi...
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| Veröffentlicht in: | The EMBO journal 1990-04, Vol.9 (4), p.1021-1026 |
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| creator | Matter, J.M. Matter‐Sadzinski, L. Ballivet, M. |
| description | Expression of the neuronal non‐alpha nicotinic acetylcholine receptor (n alpha nAChR) gene is transiently stimulated in the chick optic tectum between embryonic days 7 and 16 with a peak value reached around embryonic day 12. This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the n alpha nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of n alpha nAChR gene does not take place in the optic tectum of ‘eyeless’ embryos. The results of our study suggest that the neuronal n alpha nAChR gene may play a role in neurogenesis of retino‐tectal connections. |
| doi_str_mv | 10.1002/j.1460-2075.1990.tb08205.x |
| format | Article |
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This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the n alpha nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of n alpha nAChR gene does not take place in the optic tectum of ‘eyeless’ embryos. 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Psychology ; Gene expression ; Gene Expression Regulation ; Molecular and cellular biology ; Molecular genetics ; Mutation ; Neurons - physiology ; Nucleic Acid Hybridization ; Receptors, Nicotinic - genetics ; Reference Values ; Retina - embryology ; Retina - metabolism ; RNA - genetics ; RNA - isolation & purification ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Superior Colliculi - embryology ; Superior Colliculi - metabolism ; Transcription, Genetic</subject><ispartof>The EMBO journal, 1990-04, Vol.9 (4), p.1021-1026</ispartof><rights>1990 European Molecular Biology Organization</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5385-29683d30c08f8738196734922344bc592a64c31a9ca1b1c67f1d1c333f8c280c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC551773/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC551773/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6890299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1691091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matter, J.M.</creatorcontrib><creatorcontrib>Matter‐Sadzinski, L.</creatorcontrib><creatorcontrib>Ballivet, M.</creatorcontrib><title>Expression of neuronal nicotinic acetylcholine receptor genes in the developing chick visual system</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><description>Expression of the neuronal non‐alpha nicotinic acetylcholine receptor (n alpha nAChR) gene is transiently stimulated in the chick optic tectum between embryonic days 7 and 16 with a peak value reached around embryonic day 12. This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the n alpha nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of n alpha nAChR gene does not take place in the optic tectum of ‘eyeless’ embryos. The results of our study suggest that the neuronal n alpha nAChR gene may play a role in neurogenesis of retino‐tectal connections.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Chick Embryo</subject><subject>Eye - embryology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutation</subject><subject>Neurons - physiology</subject><subject>Nucleic Acid Hybridization</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Reference Values</subject><subject>Retina - embryology</subject><subject>Retina - metabolism</subject><subject>RNA - genetics</subject><subject>RNA - isolation & purification</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Superior Colliculi - embryology</subject><subject>Superior Colliculi - metabolism</subject><subject>Transcription, Genetic</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU2rEzEUhoMo13r1JwhBxN2M-ZhkEsHF9VK_uOJG1yE9zbSpaTImM7X9905tqboSN0ngfd7DCQ9CzyipKSHs5aamjSQVI62oqdakHhZEMSLq_T00u0T30YwwSauGKv0QPSplQwgRqqVX6IpKTYmmMwTzfZ9dKT5FnDoc3ZhTtAFHD2nw04ktuOEQYJ2Cjw5nB64fUsYrF13BPuJh7fDS7VxIvY8rDGsP3_DOl3GaUg5lcNvH6EFnQ3FPzvc1-vp2_uX2fXX3-d2H25u7CgRXomJaKr7kBIjqVMsV1bLljWaMN80ChGZWNsCp1WDpgoJsO7qkwDnvFDBFgF-j16e5_bjYuiW4OGQbTJ_91uaDSdabv5Po12aVdkYI2rZ86r8493P6ProymK0v4EKw0aWxmFa3RGpF_wlSoSXXQk3gqxMIOZWSXXdZhhJzVGk25ujLHH2Zo0pzVmn2U_npn9_5XT25m_Ln59wWsKHLNoIvF0wqTZjWE3Zzwn744A7_sYCZf3rz8deb_wSSBr3T</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Matter, J.M.</creator><creator>Matter‐Sadzinski, L.</creator><creator>Ballivet, M.</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199004</creationdate><title>Expression of neuronal nicotinic acetylcholine receptor genes in the developing chick visual system</title><author>Matter, J.M. ; Matter‐Sadzinski, L. ; Ballivet, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5385-29683d30c08f8738196734922344bc592a64c31a9ca1b1c67f1d1c333f8c280c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Chick Embryo</topic><topic>Eye - embryology</topic><topic>Fundamental and applied biological sciences. 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This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the n alpha nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of n alpha nAChR gene does not take place in the optic tectum of ‘eyeless’ embryos. The results of our study suggest that the neuronal n alpha nAChR gene may play a role in neurogenesis of retino‐tectal connections.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>1691091</pmid><doi>10.1002/j.1460-2075.1990.tb08205.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Blotting, Northern Chick Embryo Eye - embryology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Molecular and cellular biology Molecular genetics Mutation Neurons - physiology Nucleic Acid Hybridization Receptors, Nicotinic - genetics Reference Values Retina - embryology Retina - metabolism RNA - genetics RNA - isolation & purification RNA, Messenger - analysis RNA, Messenger - genetics Superior Colliculi - embryology Superior Colliculi - metabolism Transcription, Genetic |
| title | Expression of neuronal nicotinic acetylcholine receptor genes in the developing chick visual system |
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