Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences
Purpose To assess the added value of intraoperative optical coherence tomography (iOCT) in evaluating graft adhesion and graft interface in patients undergoing descemet’s stripping automated endothelial keratoplasty (DSAEK). Methods This is a prospective single-center case series comprising 8 eyes o...
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| Veröffentlicht in: | International ophthalmology 2017-08, Vol.37 (4), p.939-944 |
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| creator | Steverink, Jasper G. Wisse, Robert P. L. |
| description | Purpose
To assess the added value of intraoperative optical coherence tomography (iOCT) in evaluating graft adhesion and graft interface in patients undergoing descemet’s stripping automated endothelial keratoplasty (DSAEK).
Methods
This is a prospective single-center case series comprising 8 eyes of 8 patients consecutively scheduled for DSAEK surgery. iOCT imaging was performed after insertion of the graft, after pressurizing the eye, and at the end of surgery (three images per surgery). At each stage of surgery, corneal thickness and the widest gap between the recipient and the graft (i.e., maximal interface width) were measured using an image processing tool. Follow-up measurements were taken at 1 day, 3 and 6 months, post-operatively.
Results
Imaging was performed in 21 of 24 scheduled imaging intervals, and required little to no additional surgical time. At the end of surgery, iOCT showed persisting interfaces in six cases. One case showed a full graft detachment necessitating surgical intervention.
Conclusion
Real-time iOCT is a safe, efficient, and useful tool in assessing graft adherence in DSAEK surgery. With adequate analysis software, iOCT has the potential to be a paradigm-shifting development in posterior lamellar surgery and could aid the clinician in further lowering the rates of graft dislocation after DSAEK. |
| doi_str_mv | 10.1007/s10792-016-0338-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5517607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1920050873</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-77800198a193ef5ea2233bfcbe1591b658cb45f1a66850c26b49e40fd68cf89c3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EokvhB3BBlrhwCYyT9RcHJFTxUalSL-VsOc5k1yWJg-0U9t_X0ZaqReLkwzzzjGdeQl4zeM8A5IfEQOq6AiYqaBpV6Sdkw7hsqlo08JRsSoFXXAI7IS9SugYALbV4Tk5qKTivtdqQ3-dTjjbMGG32N0jDnL2zA3VhjxEnhzSHMeyinfcH6ifaYXI4YqYpRz_PftpRuxTEZuwoTl3Iexx8EfxcjWEebMqHj3T2Q8gU_5Q5frWml-RZb4eEr-7eU_Lj65ers-_VxeW387PPF5XbSsiVlAqAaWWZbrDnaOu6adretci4Zq3gyrVb3jMrhOLgatFuNW6h74RyvdKuOSWfjt55aUfsHK7rDmaOfrTxYIL15nFl8nuzCzeGcyYFyCJ4dyeI4deCKZvRlxMMg50wLMkwxbVknCtV0Lf_oNdhiVNZzzBdA3BQsikUO1IuhpQi9vefYWDWWM0xVlPSM2usRpeeNw-3uO_4m2MB6iOQSmnaYXww-r_WWyr5sZc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920050873</pqid></control><display><type>article</type><title>Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Steverink, Jasper G. ; Wisse, Robert P. L.</creator><creatorcontrib>Steverink, Jasper G. ; Wisse, Robert P. L.</creatorcontrib><description>Purpose
To assess the added value of intraoperative optical coherence tomography (iOCT) in evaluating graft adhesion and graft interface in patients undergoing descemet’s stripping automated endothelial keratoplasty (DSAEK).
Methods
This is a prospective single-center case series comprising 8 eyes of 8 patients consecutively scheduled for DSAEK surgery. iOCT imaging was performed after insertion of the graft, after pressurizing the eye, and at the end of surgery (three images per surgery). At each stage of surgery, corneal thickness and the widest gap between the recipient and the graft (i.e., maximal interface width) were measured using an image processing tool. Follow-up measurements were taken at 1 day, 3 and 6 months, post-operatively.
Results
Imaging was performed in 21 of 24 scheduled imaging intervals, and required little to no additional surgical time. At the end of surgery, iOCT showed persisting interfaces in six cases. One case showed a full graft detachment necessitating surgical intervention.
Conclusion
Real-time iOCT is a safe, efficient, and useful tool in assessing graft adherence in DSAEK surgery. With adequate analysis software, iOCT has the potential to be a paradigm-shifting development in posterior lamellar surgery and could aid the clinician in further lowering the rates of graft dislocation after DSAEK.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-016-0338-9</identifier><identifier>PMID: 27655298</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adhesion tests ; Aged ; Automatic pilots ; Automation ; Coherence ; Cornea ; Cornea - pathology ; Cornea - surgery ; Corneal transplantation ; Descemet Stripping Endothelial Keratoplasty - methods ; Dislocation ; Dislocations ; Eye ; Eye surgery ; Female ; Follow-Up Studies ; Fuchs' Endothelial Dystrophy - diagnosis ; Fuchs' Endothelial Dystrophy - surgery ; Grafting ; Humans ; Image processing ; Imaging ; Interfaces ; Intervention ; Intraoperative Period ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmology ; Optical Coherence Tomography ; Original Paper ; Patients ; Pilot Projects ; Pressurization ; Prospective Studies ; Software ; Stripping ; Surgery ; Surgical instruments ; Tissue Adhesions - diagnosis ; Tissue Adhesions - pathology ; Tomography ; Tomography, Optical Coherence - methods</subject><ispartof>International ophthalmology, 2017-08, Vol.37 (4), p.939-944</ispartof><rights>The Author(s) 2016</rights><rights>International Ophthalmology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-77800198a193ef5ea2233bfcbe1591b658cb45f1a66850c26b49e40fd68cf89c3</citedby><cites>FETCH-LOGICAL-c470t-77800198a193ef5ea2233bfcbe1591b658cb45f1a66850c26b49e40fd68cf89c3</cites><orcidid>0000-0002-2844-9868</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-016-0338-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-016-0338-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27655298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steverink, Jasper G.</creatorcontrib><creatorcontrib>Wisse, Robert P. L.</creatorcontrib><title>Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To assess the added value of intraoperative optical coherence tomography (iOCT) in evaluating graft adhesion and graft interface in patients undergoing descemet’s stripping automated endothelial keratoplasty (DSAEK).
Methods
This is a prospective single-center case series comprising 8 eyes of 8 patients consecutively scheduled for DSAEK surgery. iOCT imaging was performed after insertion of the graft, after pressurizing the eye, and at the end of surgery (three images per surgery). At each stage of surgery, corneal thickness and the widest gap between the recipient and the graft (i.e., maximal interface width) were measured using an image processing tool. Follow-up measurements were taken at 1 day, 3 and 6 months, post-operatively.
Results
Imaging was performed in 21 of 24 scheduled imaging intervals, and required little to no additional surgical time. At the end of surgery, iOCT showed persisting interfaces in six cases. One case showed a full graft detachment necessitating surgical intervention.
Conclusion
Real-time iOCT is a safe, efficient, and useful tool in assessing graft adherence in DSAEK surgery. With adequate analysis software, iOCT has the potential to be a paradigm-shifting development in posterior lamellar surgery and could aid the clinician in further lowering the rates of graft dislocation after DSAEK.</description><subject>Adhesion tests</subject><subject>Aged</subject><subject>Automatic pilots</subject><subject>Automation</subject><subject>Coherence</subject><subject>Cornea</subject><subject>Cornea - pathology</subject><subject>Cornea - surgery</subject><subject>Corneal transplantation</subject><subject>Descemet Stripping Endothelial Keratoplasty - methods</subject><subject>Dislocation</subject><subject>Dislocations</subject><subject>Eye</subject><subject>Eye surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fuchs' Endothelial Dystrophy - diagnosis</subject><subject>Fuchs' Endothelial Dystrophy - surgery</subject><subject>Grafting</subject><subject>Humans</subject><subject>Image processing</subject><subject>Imaging</subject><subject>Interfaces</subject><subject>Intervention</subject><subject>Intraoperative Period</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Optical Coherence Tomography</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Pilot Projects</subject><subject>Pressurization</subject><subject>Prospective Studies</subject><subject>Software</subject><subject>Stripping</subject><subject>Surgery</subject><subject>Surgical instruments</subject><subject>Tissue Adhesions - diagnosis</subject><subject>Tissue Adhesions - pathology</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi0EokvhB3BBlrhwCYyT9RcHJFTxUalSL-VsOc5k1yWJg-0U9t_X0ZaqReLkwzzzjGdeQl4zeM8A5IfEQOq6AiYqaBpV6Sdkw7hsqlo08JRsSoFXXAI7IS9SugYALbV4Tk5qKTivtdqQ3-dTjjbMGG32N0jDnL2zA3VhjxEnhzSHMeyinfcH6ifaYXI4YqYpRz_PftpRuxTEZuwoTl3Iexx8EfxcjWEebMqHj3T2Q8gU_5Q5frWml-RZb4eEr-7eU_Lj65ers-_VxeW387PPF5XbSsiVlAqAaWWZbrDnaOu6adretci4Zq3gyrVb3jMrhOLgatFuNW6h74RyvdKuOSWfjt55aUfsHK7rDmaOfrTxYIL15nFl8nuzCzeGcyYFyCJ4dyeI4deCKZvRlxMMg50wLMkwxbVknCtV0Lf_oNdhiVNZzzBdA3BQsikUO1IuhpQi9vefYWDWWM0xVlPSM2usRpeeNw-3uO_4m2MB6iOQSmnaYXww-r_WWyr5sZc</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Steverink, Jasper G.</creator><creator>Wisse, Robert P. L.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2844-9868</orcidid></search><sort><creationdate>20170801</creationdate><title>Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences</title><author>Steverink, Jasper G. ; Wisse, Robert P. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-77800198a193ef5ea2233bfcbe1591b658cb45f1a66850c26b49e40fd68cf89c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adhesion tests</topic><topic>Aged</topic><topic>Automatic pilots</topic><topic>Automation</topic><topic>Coherence</topic><topic>Cornea</topic><topic>Cornea - pathology</topic><topic>Cornea - surgery</topic><topic>Corneal transplantation</topic><topic>Descemet Stripping Endothelial Keratoplasty - methods</topic><topic>Dislocation</topic><topic>Dislocations</topic><topic>Eye</topic><topic>Eye surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fuchs' Endothelial Dystrophy - diagnosis</topic><topic>Fuchs' Endothelial Dystrophy - surgery</topic><topic>Grafting</topic><topic>Humans</topic><topic>Image processing</topic><topic>Imaging</topic><topic>Interfaces</topic><topic>Intervention</topic><topic>Intraoperative Period</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Optical Coherence Tomography</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Pilot Projects</topic><topic>Pressurization</topic><topic>Prospective Studies</topic><topic>Software</topic><topic>Stripping</topic><topic>Surgery</topic><topic>Surgical instruments</topic><topic>Tissue Adhesions - diagnosis</topic><topic>Tissue Adhesions - pathology</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steverink, Jasper G.</creatorcontrib><creatorcontrib>Wisse, Robert P. L.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steverink, Jasper G.</au><au>Wisse, Robert P. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>37</volume><issue>4</issue><spage>939</spage><epage>944</epage><pages>939-944</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To assess the added value of intraoperative optical coherence tomography (iOCT) in evaluating graft adhesion and graft interface in patients undergoing descemet’s stripping automated endothelial keratoplasty (DSAEK).
Methods
This is a prospective single-center case series comprising 8 eyes of 8 patients consecutively scheduled for DSAEK surgery. iOCT imaging was performed after insertion of the graft, after pressurizing the eye, and at the end of surgery (three images per surgery). At each stage of surgery, corneal thickness and the widest gap between the recipient and the graft (i.e., maximal interface width) were measured using an image processing tool. Follow-up measurements were taken at 1 day, 3 and 6 months, post-operatively.
Results
Imaging was performed in 21 of 24 scheduled imaging intervals, and required little to no additional surgical time. At the end of surgery, iOCT showed persisting interfaces in six cases. One case showed a full graft detachment necessitating surgical intervention.
Conclusion
Real-time iOCT is a safe, efficient, and useful tool in assessing graft adherence in DSAEK surgery. With adequate analysis software, iOCT has the potential to be a paradigm-shifting development in posterior lamellar surgery and could aid the clinician in further lowering the rates of graft dislocation after DSAEK.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27655298</pmid><doi>10.1007/s10792-016-0338-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2844-9868</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International ophthalmology, 2017-08, Vol.37 (4), p.939-944 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adhesion tests Aged Automatic pilots Automation Coherence Cornea Cornea - pathology Cornea - surgery Corneal transplantation Descemet Stripping Endothelial Keratoplasty - methods Dislocation Dislocations Eye Eye surgery Female Follow-Up Studies Fuchs' Endothelial Dystrophy - diagnosis Fuchs' Endothelial Dystrophy - surgery Grafting Humans Image processing Imaging Interfaces Intervention Intraoperative Period Male Medical imaging Medicine Medicine & Public Health Middle Aged Ophthalmology Optical Coherence Tomography Original Paper Patients Pilot Projects Pressurization Prospective Studies Software Stripping Surgery Surgical instruments Tissue Adhesions - diagnosis Tissue Adhesions - pathology Tomography Tomography, Optical Coherence - methods |
| title | Intraoperative optical coherence tomography in descemet stripping automated endothelial keratoplasty: pilot experiences |
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