Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C–H Cross-Coupling

A Pd­(II)-catalyzed enantioselective C–H cross-coupling of benzylamines via kinetic resolution has been achieved using chiral mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands. Both chiral benzylamines and ortho-arylated benzylamines are obtained in high enantiomeric purity. The use o...

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Veröffentlicht in:	Journal of the American Chemical Society 2016-06, Vol.138 (24), p.7796-7800
Hauptverfasser:	Xiao, Kai-Jiong, Chu, Ling, Chen, Gang, Yu, Jin-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Benzylamines - chemistry Catalysis Cross-Linking Reagents - chemistry Drug Design enantiomers Hydroxamic Acids - chemistry Kinetics Ligands Molecular Structure palladium Palladium - chemistry Stereoisomerism
Online-Zugang:	Volltext
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