Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis

The gain-of-function mucin 5B (MUC5B) promoter variant, rs35705950, confers the largest risk, genetic or otherwise, for the development of idiopathic pulmonary fibrosis; however, the mechanisms underlying the regulation of MUC5B expression have yet to be elucidated. Here, we identify a critical regu...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2017-07, Vol.57 (1), p.91-99
Hauptverfasser:	Helling, Britney A, Gerber, Anthony N, Kadiyala, Vineela, Sasse, Sarah K, Pedersen, Brent S, Sparks, Lenore, Nakano, Yasushi, Okamoto, Tsukasa, Evans, Christopher M, Yang, Ivana V, Schwartz, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Base Sequence Binding Sites Chromatin Immunoprecipitation Consortia CpG Islands - genetics Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Epigenetics Fibrosis Forkhead protein Gene expression Gene Knockdown Techniques Genomes Hepatocyte Nuclear Factor 3-beta - metabolism Humans Idiopathic Pulmonary Fibrosis - genetics Lung - metabolism Lung - pathology Lung diseases Mucin Mucin-5B - genetics Mucin-5B - metabolism Original Research Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic Protein Binding - genetics Proteins Pulmonary fibrosis RNA polymerase RNA Polymerase II - metabolism RNA, Small Interfering - metabolism Transcription factors Transplants & implants
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