Assessment of the Pharmacokinetics, Pharmacodynamics, and Safety of Single Doses of TV‐1106, a Long‐Acting Growth Hormone, in Healthy Japanese and Caucasian Subjects

TV‐1106 is a human serum albumin genetically fused to recombinant human growth hormone, designed to provide a long‐acting alternative to daily growth hormone (GH) injections in patients with GH deficiency. This study investigated the pharmacokinetics, pharmacodynamics, and safety of single subcutane...

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Veröffentlicht in:	Clinical pharmacology in drug development 2017-07, Vol.6 (4), p.331-342
Hauptverfasser:	Cohen‐Barak, Orit, Barkay, Hadas, Rasamoelisolo, Michele, Butler, Kathleen, Yamada, Kazumasa, Bassan, Merav, Yoon, Esther, Spiegelstein, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asian Continental Ancestry Group Dose-Response Relationship, Drug European Continental Ancestry Group Female growth hormone deficiency (GHD) Growth hormones Healthy Volunteers Human Growth Hormone - genetics Human Growth Hormone - metabolism Humans Injections, Subcutaneous Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor I - metabolism Insulin-like growth factors insulin‐like growth factor (IGF‐1) Japanese Male Original Manuscript Pharmacodynamics Pharmacokinetics Pharmacology Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - adverse effects Recombinant Fusion Proteins - pharmacokinetics Serum Albumin, Human - genetics Serum Albumin, Human - metabolism TV‐1106 weekly hGH White people Young Adult
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