Bayesian nonparametric clustering in phylogenetics: modeling antigenic evolution in influenza

Influenza is responsible for up to 500,000 deaths every year, and antigenic variability represents much of its epidemiological burden. To visualize antigenic differences across many viral strains, antigenic cartography methods use multidimensional scaling on binding assay data to map influenza antig...

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Veröffentlicht in:	Statistics in medicine 2018-01, Vol.37 (2), p.195-206
Hauptverfasser:	Cybis, Gabriela B., Sinsheimer, Janet S., Bedford, Trevor, Rambaut, Andrew, Lemey, Philippe, Suchard, Marc A.
Format:	Artikel
Sprache:	eng
Schlagworte:	antigenic cartography Antigens Antigens, Viral - genetics Antigens, Viral - immunology Bayes Theorem Bayesian nonparametric mixture models Biostatistics Cluster Analysis Epidemiology Evolution, Molecular Humans Influenza Influenza A Virus, H1N1 Subtype - classification Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza, Human - epidemiology Influenza, Human - virology Likelihood Functions Mathematical models Models, Genetic Models, Immunological Molecular Epidemiology Nonparametric statistics phylodynamics Phylogenetics Phylogeny Statistics, Nonparametric Stochastic Processes
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