The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance

Chronic rejection is associated with persistent mononuclear cell recruitment, endothelial activation and proliferation, local tissue hypoxia and related biology that enhance effector immune responses. In contrast, the tumor microenvironment elicits signals/factors that inhibit effector T cell respon...

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Veröffentlicht in:	Current opinion in organ transplantation 2017-02, Vol.22 (1), p.55-63
Hauptverfasser:	Wedel, Johannes, Nakayama, Hironao, Kochupurakkal, Nora M., Koch, Josephine, Klagsbrun, Michael, Bielenberg, Diane R., Briscoe, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Graft Rejection - immunology Humans Immune Tolerance - immunology Tumor Microenvironment
Online-Zugang:	Volltext
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