Cardiovascular Disease in Acromegaly
In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart f...
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| Veröffentlicht in: | Methodist DeBakey cardiovascular journal 2017-04, Vol.13 (2), p.64-67 |
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| container_title | Methodist DeBakey cardiovascular journal |
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| creator | Sharma, Morali D Nguyen, Anh V Brown, Spandana Robbins, Richard J |
| description | In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications. |
| doi_str_mv | 10.14797/mdcj-13-2-64 |
| format | Article |
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Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. 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Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.</description><subject>Acromegaly - blood</subject><subject>Acromegaly - diagnosis</subject><subject>Acromegaly - epidemiology</subject><subject>Acromegaly - physiopathology</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular System - metabolism</subject><subject>Cardiovascular System - physiopathology</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Prognosis</subject><subject>Risk Factors</subject><issn>1947-6094</issn><issn>1947-6108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLAzEQxoMottQevUoPHrxE85jNbi5CqU8oeNFzmGSzdcs-atIt9L93tQ90LjMwP7755iPkkrNbDqlO7-rcLSmXVFAFJ2TINaRUcZadHmamYUDGMS5ZXzLlqWLnZCCyFFiSwZBczzDkZbvB6LoKw-ShjB6jn5TNZOpCW_sFVtsLclZgFf1430fk4-nxffZC52_Pr7PpnDrJBFAHILkutIMkUdYpJ5SwhUUQaW6tAwsOZQFWouDMomVJDoplKJxCn7NMjsj9TnfV2drnzjfrgJVZhbLGsDUtlub_pik_zaLdmCThQmW8F7jZC4T2q_NxbeoyOl9V2Pi2i4ZrITmXWqkepTu0_zLG4IvjGc7Mb7jmJ1zDpRFGQc9f_fV2pA9Rym8dc3XO</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Sharma, Morali D</creator><creator>Nguyen, Anh V</creator><creator>Brown, Spandana</creator><creator>Robbins, Richard J</creator><general>The Methodist Hospital Houston, Texas</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170401</creationdate><title>Cardiovascular Disease in Acromegaly</title><author>Sharma, Morali D ; Nguyen, Anh V ; Brown, Spandana ; Robbins, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3024-c44319f9c4556bc6c262bfba427dbbc4b4ca3f4b3a210bab05d4608a2c6aed083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acromegaly - blood</topic><topic>Acromegaly - diagnosis</topic><topic>Acromegaly - epidemiology</topic><topic>Acromegaly - physiopathology</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular System - metabolism</topic><topic>Cardiovascular System - physiopathology</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Prognosis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Morali D</creatorcontrib><creatorcontrib>Nguyen, Anh V</creatorcontrib><creatorcontrib>Brown, Spandana</creatorcontrib><creatorcontrib>Robbins, Richard J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Methodist DeBakey cardiovascular journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Morali D</au><au>Nguyen, Anh V</au><au>Brown, Spandana</au><au>Robbins, Richard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Disease in Acromegaly</atitle><jtitle>Methodist DeBakey cardiovascular journal</jtitle><addtitle>Methodist Debakey Cardiovasc J</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>13</volume><issue>2</issue><spage>64</spage><epage>67</epage><pages>64-67</pages><issn>1947-6094</issn><eissn>1947-6108</eissn><abstract>In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. 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| fulltext | fulltext |
| identifier | ISSN: 1947-6094 |
| ispartof | Methodist DeBakey cardiovascular journal, 2017-04, Vol.13 (2), p.64-67 |
| issn | 1947-6094 1947-6108 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Acromegaly - blood Acromegaly - diagnosis Acromegaly - epidemiology Acromegaly - physiopathology Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Cardiovascular System - metabolism Cardiovascular System - physiopathology Human Growth Hormone - blood Humans Insulin-Like Growth Factor I - metabolism Prognosis Risk Factors |
| title | Cardiovascular Disease in Acromegaly |
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