HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication

Macrophages play important roles in HIV-1 pathogenesis as targets for viral replication and mediators of chronic inflammation. Similar to IFNγ-priming, HIV-1 primes macrophages, resulting in hyperresponsiveness to subsequent toll-like receptor (TLR) stimulation and increased inflammatory cytokine pr...

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Veröffentlicht in:	AIDS research and human retroviruses 2017-07, Vol.33 (7), p.690-702
Hauptverfasser:	Appelberg, K Sofia, Wallet, Mark A, Taylor, Jared P, Cash, Melanie N, Sleasman, John W, Goodenow, Maureen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis AIDS/HIV Cell activation Cells, Cultured DNA microarrays Gene expression Gene Expression Profiling HIV HIV Infections - pathology HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Humans Immune response Immune system Infections Inflammation Inflammation - pathology Interferon Interferon-gamma - metabolism Lipopolysaccharides Macrophages Macrophages - immunology Microarray Analysis Pathogenesis Priming Proteins Replication Signal Transduction Stat1 protein STAT1 Transcription Factor - metabolism Stat3 protein STAT3 Transcription Factor - metabolism Stimulation Toll-like receptors Transcription Tumor necrosis factor Tumor necrosis factor-TNF Virus Replication
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