Cell Cycle-Dependent Expression of Adeno-Associated Virus 2 (AAV2) Rep in Coinfections with Herpes Simplex Virus 1 (HSV-1) Gives Rise to a Mosaic of Cells Replicating either AAV2 or HSV-1

Adeno-associated virus 2 (AAV2) depends on the simultaneous presence of a helper virus such as herpes simplex virus 1 (HSV-1) for productive replication. At the same time, AAV2 efficiently blocks the replication of HSV-1, which would eventually limit its own replication by diminishing the helper vir...

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Veröffentlicht in:	Journal of virology 2017-08, Vol.91 (15)
Hauptverfasser:	Franzoso, Francesca D, Seyffert, Michael, Vogel, Rebecca, Yakimovich, Artur, de Andrade Pereira, Bruna, Meier, Anita F, Sutter, Sereina O, Tobler, Kurt, Vogt, Bernd, Greber, Urs F, Büning, Hildegard, Ackermann, Mathias, Fraefel, Cornel
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Cell Line Coinfection Dependovirus - growth & development DNA-Binding Proteins - metabolism Gene Expression Genome and Regulation of Viral Gene Expression Helper Viruses - growth & development Herpesvirus 1, Human - growth & development Humans Microscopy Viral Interference Viral Proteins - metabolism Virus Cultivation Virus Replication
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