Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2

The vaccinia virus B1 kinase is highly conserved among poxviruses and is essential for the viral life cycle. B1 exhibits a remarkable degree of similarity to vaccinia virus-related kinases (VRKs), a family of cellular kinases, suggesting that the viral enzyme has evolved to mimic VRK activity. Indee...

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Veröffentlicht in:	Journal of virology 2017-08, Vol.91 (15)
Hauptverfasser:	Olson, Annabel T, Rico, Amber B, Wang, Zhigang, Delhon, Gustavo, Wiebe, Matthew S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line DNA Replication Gene Deletion Host-Pathogen Interactions Humans Protein-Serine-Threonine Kinases - metabolism Spotlight Vaccinia virus - enzymology Vaccinia virus - physiology Viral Proteins - genetics Viral Proteins - metabolism Virus Replication Virus-Cell Interactions
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