Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model

Inflammation is implicated in a host of chronic illnesses. Within these inflamed tissues, the pH of the microenvironment is decreased and immune cells, particularly macrophages, infiltrate the area. Additionally, the vascular integrity of these sites is altered with increased fenestrations between e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular pharmaceutics 2017-06, Vol.14 (6), p.1929-1937
Hauptverfasser:	O’Mary, Hannah L, Aldayel, Abdulaziz M, Valdes, Solange A, Naguib, Youssef W, Li, Xu, Salvady, Karun, Cui, Zhengrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Betamethasone - administration & dosage Betamethasone - therapeutic use Inflammation - chemically induced Inflammation - drug therapy Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Mannose - chemistry Mice Nanoparticles - chemistry Polyethylene Glycols - chemistry Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!