An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent

Bromodomain-containing protein 4 (BRD4) has recently emerged as an attractive epigenetic target for anticancer therapy. In this study, an iridium(iii) complex is reported as the first metal-based, irreversible inhibitor of BRD4. Complex is able to antagonize the BRD4-acetylated histone protein-prote...

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Veröffentlicht in:	Chemical science (Cambridge) 2015-10, Vol.6 (10), p.5400-5408
Hauptverfasser:	Zhong, Hai-Jing, Lu, Lihua, Leung, Ka-Ho, Wong, Catherine C L, Peng, Chao, Yan, Siu-Cheong, Ma, Dik-Lung, Cai, Zongwei, David Wang, Hui-Min, Leung, Chung-Hang
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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