Inhibition of inflammation induced shedding of the endothelial glycocalyx with low molecular weight heparin

The endothelial surface layer (ESL) consists of the endothelial cell (EC) glycocalyx and adsorbed proteins, and forms a barrier between blood and the EC. Enzymatic shedding of the ESL in response to cytokines may expose receptors for leukocyte (WBC) adhesion and increase vascular permeability. Thus,...

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Veröffentlicht in:	Microvascular research 2017-07, Vol.112, p.72-78
Hauptverfasser:	Lipowsky, Herbert H., Lescanic, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillary Permeability - drug effects Cell Adhesion - drug effects Disease Models, Animal Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Glycocalyx Glycocalyx - drug effects Glycocalyx - metabolism Glycocalyx - pathology Heparin Heparin, Low-Molecular-Weight - pharmacology Inflammation Inflammation - blood Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Intravital Microscopy Leukocytes - drug effects Leukocytes - metabolism Leukocytes - pathology Male Mesentery Mesentery - blood supply N-Formylmethionine Leucyl-Phenylalanine - pharmacology Polysaccharides - metabolism Rats, Wistar Time Factors Venules Venules - drug effects Venules - metabolism Venules - pathology
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