ABCB1 genotype is associated with fentanyl requirements in critically ill children

Background The gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children. Methods A...

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Veröffentlicht in:	Pediatric research 2017-07, Vol.82 (1), p.29-35
Hauptverfasser:	Horvat, Christopher M, Au, Alicia K, Conley, Yvette P, Kochanek, Patrick M, Li, Lingjue, Poloyac, Samuel M, Empey, Philip E, Clark, Robert S B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1231 631/92/436/434 692/700/1720/3187 clinical-investigation Drug delivery systems Genotype & phenotype Glycoproteins Medicine Medicine & Public Health Pediatric Surgery Pediatrics
Online-Zugang:	Volltext
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