Cardiac and Metabolic Variables in Obese Dogs
Background The etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs. Objectives To evaluate cardiac structure and function and metab...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2017-07, Vol.31 (4), p.1000-1007 |
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| creator | Tropf, M. Nelson, O.L. Lee, P.M. Weng, H.Y. |
| description | Background
The etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs.
Objectives
To evaluate cardiac structure and function and metabolic variables in obese dogs compared to ideal weight dogs.
Animals
Forty‐six healthy, small‐breed ( |
| doi_str_mv | 10.1111/jvim.14775 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5508341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1909235841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4205-359bb2e71748a16d793324392b86ba5ea8708833f431c889cd83423d32b2e4c23</originalsourceid><addsrcrecordid>eNp9kE1PAjEQhhujEUQv_gCzR2Oy2O-Pi4nBLwyEi3Jt2m7BkmUXt4Dh37uwSPTiXOYwzzwzeQG4RLCL6rqdrcO8i6gQ7Ai0kSIqRVzwY9CGUqGUcwpb4CzGGYSYMSZOQQtLDiUnrA3SnqmyYFxiiiwZ-qWxZR5cMjZVMDb3MQlFMrI--uShnMZzcDIxefQX-94B70-Pb72XdDB67vfuB6mjGLKUMGUt9gIJKg3imVCEYEoUtpJbw7yRAkpJyIQS5KRULpOEYpIRXG9Rh0kH3DXexcrOfeZ8saxMrhdVmJtqo0sT9N9JET70tFxrxmCtQrXgei-oys-Vj0s9D9H5PDeFL1dRIwUVJkzu0JsGdVUZY-UnhzMI6m2-epuv3uVbw1e_HzugP4HWAGqAr5D7zT8q_TruDxvpN2xvg_U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1909235841</pqid></control><display><type>article</type><title>Cardiac and Metabolic Variables in Obese Dogs</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Tropf, M. ; Nelson, O.L. ; Lee, P.M. ; Weng, H.Y.</creator><creatorcontrib>Tropf, M. ; Nelson, O.L. ; Lee, P.M. ; Weng, H.Y.</creatorcontrib><description>Background
The etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs.
Objectives
To evaluate cardiac structure and function and metabolic variables in obese dogs compared to ideal weight dogs.
Animals
Forty‐six healthy, small‐breed (<25 pounds), obese dogs (n = 29) compared to ideal weight dogs (n = 17).
Methods
A cross‐sectional study of cardiac structure and function by standard and strain echocardiographic measurements and quantification of serum metabolic variables (insulin:glucose ratios, lipid analysis, adiponectin, inflammatory markers).
Results
Compared to the ideal weight controls, obese dogs had cardiac changes characterized by an increased interventricular septal width in diastole to left ventricular internal dimension in diastole ratio, decreased ratios of peak early to peak late left ventricular inflow velocities, and ratios of peak early to peak late mitral annular tissue velocities, and increased fractional shortening and ejection fraction percentages. The left ventricular posterior wall width in diastole to left ventricular internal dimension in diastole ratios were not significantly different between groups. Systolic blood pressure was not significantly different between groups. Obese dogs had metabolic derangements characterized by increased insulin:glucose ratios, dyslipidemias with increased cholesterol, triglyceride, and high‐density lipoprotein concentrations, decreased adiponectin concentrations, and increased concentrations of interleukin 8 and keratinocyte‐derived chemokine‐like inflammatory cytokines.
Conclusions and Clinical Importance
Compared to ideal weight controls, obese dogs have alterations in cardiac structure and function as well as insulin resistance, dyslipidemia, hypoadiponectinemia, and increased concentrations of inflammatory markers. These findings warrant additional studies to investigate inflammation, dyslipidemia, and possibly systemic hypertension as potential contributing factors for altered cardiac function.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.14775</identifier><identifier>PMID: 28608635</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adiponectin - blood ; Animals ; Blood Glucose - analysis ; Blood Pressure - physiology ; Case-Control Studies ; Dog Diseases - blood ; Dog Diseases - metabolism ; Dog Diseases - physiopathology ; Dogs ; Echocardiography - veterinary ; Female ; Heart - physiopathology ; Insulin - blood ; Lipids - blood ; Male ; Metabolic syndrome ; Obesity - blood ; Obesity - metabolism ; Obesity - physiopathology ; Obesity - veterinary ; Obesity‐related cardiac dysfunction ; SMALL ANIMAL</subject><ispartof>Journal of veterinary internal medicine, 2017-07, Vol.31 (4), p.1000-1007</ispartof><rights>Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4205-359bb2e71748a16d793324392b86ba5ea8708833f431c889cd83423d32b2e4c23</citedby><cites>FETCH-LOGICAL-c4205-359bb2e71748a16d793324392b86ba5ea8708833f431c889cd83423d32b2e4c23</cites><orcidid>0000-0001-6003-0496 ; 0000-0002-5264-4903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28608635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tropf, M.</creatorcontrib><creatorcontrib>Nelson, O.L.</creatorcontrib><creatorcontrib>Lee, P.M.</creatorcontrib><creatorcontrib>Weng, H.Y.</creatorcontrib><title>Cardiac and Metabolic Variables in Obese Dogs</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
The etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs.
Objectives
To evaluate cardiac structure and function and metabolic variables in obese dogs compared to ideal weight dogs.
Animals
Forty‐six healthy, small‐breed (<25 pounds), obese dogs (n = 29) compared to ideal weight dogs (n = 17).
Methods
A cross‐sectional study of cardiac structure and function by standard and strain echocardiographic measurements and quantification of serum metabolic variables (insulin:glucose ratios, lipid analysis, adiponectin, inflammatory markers).
Results
Compared to the ideal weight controls, obese dogs had cardiac changes characterized by an increased interventricular septal width in diastole to left ventricular internal dimension in diastole ratio, decreased ratios of peak early to peak late left ventricular inflow velocities, and ratios of peak early to peak late mitral annular tissue velocities, and increased fractional shortening and ejection fraction percentages. The left ventricular posterior wall width in diastole to left ventricular internal dimension in diastole ratios were not significantly different between groups. Systolic blood pressure was not significantly different between groups. Obese dogs had metabolic derangements characterized by increased insulin:glucose ratios, dyslipidemias with increased cholesterol, triglyceride, and high‐density lipoprotein concentrations, decreased adiponectin concentrations, and increased concentrations of interleukin 8 and keratinocyte‐derived chemokine‐like inflammatory cytokines.
Conclusions and Clinical Importance
Compared to ideal weight controls, obese dogs have alterations in cardiac structure and function as well as insulin resistance, dyslipidemia, hypoadiponectinemia, and increased concentrations of inflammatory markers. These findings warrant additional studies to investigate inflammation, dyslipidemia, and possibly systemic hypertension as potential contributing factors for altered cardiac function.</description><subject>Adiponectin - blood</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure - physiology</subject><subject>Case-Control Studies</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - metabolism</subject><subject>Dog Diseases - physiopathology</subject><subject>Dogs</subject><subject>Echocardiography - veterinary</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Insulin - blood</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Obesity - veterinary</subject><subject>Obesity‐related cardiac dysfunction</subject><subject>SMALL ANIMAL</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kE1PAjEQhhujEUQv_gCzR2Oy2O-Pi4nBLwyEi3Jt2m7BkmUXt4Dh37uwSPTiXOYwzzwzeQG4RLCL6rqdrcO8i6gQ7Ai0kSIqRVzwY9CGUqGUcwpb4CzGGYSYMSZOQQtLDiUnrA3SnqmyYFxiiiwZ-qWxZR5cMjZVMDb3MQlFMrI--uShnMZzcDIxefQX-94B70-Pb72XdDB67vfuB6mjGLKUMGUt9gIJKg3imVCEYEoUtpJbw7yRAkpJyIQS5KRULpOEYpIRXG9Rh0kH3DXexcrOfeZ8saxMrhdVmJtqo0sT9N9JET70tFxrxmCtQrXgei-oys-Vj0s9D9H5PDeFL1dRIwUVJkzu0JsGdVUZY-UnhzMI6m2-epuv3uVbw1e_HzugP4HWAGqAr5D7zT8q_TruDxvpN2xvg_U</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Tropf, M.</creator><creator>Nelson, O.L.</creator><creator>Lee, P.M.</creator><creator>Weng, H.Y.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6003-0496</orcidid><orcidid>https://orcid.org/0000-0002-5264-4903</orcidid></search><sort><creationdate>201707</creationdate><title>Cardiac and Metabolic Variables in Obese Dogs</title><author>Tropf, M. ; Nelson, O.L. ; Lee, P.M. ; Weng, H.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4205-359bb2e71748a16d793324392b86ba5ea8708833f431c889cd83423d32b2e4c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adiponectin - blood</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure - physiology</topic><topic>Case-Control Studies</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - metabolism</topic><topic>Dog Diseases - physiopathology</topic><topic>Dogs</topic><topic>Echocardiography - veterinary</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Insulin - blood</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Obesity - veterinary</topic><topic>Obesity‐related cardiac dysfunction</topic><topic>SMALL ANIMAL</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tropf, M.</creatorcontrib><creatorcontrib>Nelson, O.L.</creatorcontrib><creatorcontrib>Lee, P.M.</creatorcontrib><creatorcontrib>Weng, H.Y.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tropf, M.</au><au>Nelson, O.L.</au><au>Lee, P.M.</au><au>Weng, H.Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac and Metabolic Variables in Obese Dogs</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2017-07</date><risdate>2017</risdate><volume>31</volume><issue>4</issue><spage>1000</spage><epage>1007</epage><pages>1000-1007</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
The etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs.
Objectives
To evaluate cardiac structure and function and metabolic variables in obese dogs compared to ideal weight dogs.
Animals
Forty‐six healthy, small‐breed (<25 pounds), obese dogs (n = 29) compared to ideal weight dogs (n = 17).
Methods
A cross‐sectional study of cardiac structure and function by standard and strain echocardiographic measurements and quantification of serum metabolic variables (insulin:glucose ratios, lipid analysis, adiponectin, inflammatory markers).
Results
Compared to the ideal weight controls, obese dogs had cardiac changes characterized by an increased interventricular septal width in diastole to left ventricular internal dimension in diastole ratio, decreased ratios of peak early to peak late left ventricular inflow velocities, and ratios of peak early to peak late mitral annular tissue velocities, and increased fractional shortening and ejection fraction percentages. The left ventricular posterior wall width in diastole to left ventricular internal dimension in diastole ratios were not significantly different between groups. Systolic blood pressure was not significantly different between groups. Obese dogs had metabolic derangements characterized by increased insulin:glucose ratios, dyslipidemias with increased cholesterol, triglyceride, and high‐density lipoprotein concentrations, decreased adiponectin concentrations, and increased concentrations of interleukin 8 and keratinocyte‐derived chemokine‐like inflammatory cytokines.
Conclusions and Clinical Importance
Compared to ideal weight controls, obese dogs have alterations in cardiac structure and function as well as insulin resistance, dyslipidemia, hypoadiponectinemia, and increased concentrations of inflammatory markers. These findings warrant additional studies to investigate inflammation, dyslipidemia, and possibly systemic hypertension as potential contributing factors for altered cardiac function.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>28608635</pmid><doi>10.1111/jvim.14775</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6003-0496</orcidid><orcidid>https://orcid.org/0000-0002-5264-4903</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Adiponectin - blood Animals Blood Glucose - analysis Blood Pressure - physiology Case-Control Studies Dog Diseases - blood Dog Diseases - metabolism Dog Diseases - physiopathology Dogs Echocardiography - veterinary Female Heart - physiopathology Insulin - blood Lipids - blood Male Metabolic syndrome Obesity - blood Obesity - metabolism Obesity - physiopathology Obesity - veterinary Obesity‐related cardiac dysfunction SMALL ANIMAL |
| title | Cardiac and Metabolic Variables in Obese Dogs |
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